Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

Tick-borne encephalitis: One vaccine protects against multiple flaviviruses Prior exposure to tick-borne encephalitis virus confers immunity to distinct, but genetically related, significant human pathogens. The tick-borne encephalitis complex comprises multiple ‘flaviviruses’; however, a licensed v...

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Autores principales:	Alexander J. McAuley, Bevan Sawatsky, Thomas Ksiazek, Maricela Torres, Miša Korva, Stanka Lotrič-Furlan, Tatjana Avšič-Županc, Veronika von Messling, Michael R. Holbrook, Alexander N. Freiberg, David W. C. Beasley, Dennis A. Bente
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a72ff5e911e648228cdfd515419ac629
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spelling	oai:doaj.org-article:a72ff5e911e648228cdfd515419ac6292021-12-02T11:50:55ZCross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection10.1038/s41541-017-0009-52059-0105https://doaj.org/article/a72ff5e911e648228cdfd515419ac6292017-03-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0009-5https://doaj.org/toc/2059-0105Tick-borne encephalitis: One vaccine protects against multiple flaviviruses Prior exposure to tick-borne encephalitis virus confers immunity to distinct, but genetically related, significant human pathogens. The tick-borne encephalitis complex comprises multiple ‘flaviviruses’; however, a licensed vaccine only exists for one: tick-borne encephalitis virus (TBEV). Alexander McAuley, of the University of Texas Medical Branch, USA, and collaborators tested human serum samples from donors who had either received the TBEV vaccine, been infected with the virus naturally, or had contracted the virus despite prior vaccination. The team tested the sera against six genetically related flaviviruses, looking for antibodies that indicate viral immunity. The results showed that TBEV exposure induce production of antibodies that inhibit other flaviviruses, the efficacy of which decreases as the genetic variation from TBEV increases. Additionally, sera from infected individuals generated more antibodies than sera from vaccinated donors. This study provides an insight into the relationship between genetic similarity and vaccine cross-protection.Alexander J. McAuleyBevan SawatskyThomas KsiazekMaricela TorresMiša KorvaStanka Lotrič-FurlanTatjana Avšič-ŽupancVeronika von MesslingMichael R. HolbrookAlexander N. FreibergDavid W. C. BeasleyDennis A. BenteNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alexander J. McAuley Bevan Sawatsky Thomas Ksiazek Maricela Torres Miša Korva Stanka Lotrič-Furlan Tatjana Avšič-Županc Veronika von Messling Michael R. Holbrook Alexander N. Freiberg David W. C. Beasley Dennis A. Bente Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
description	Tick-borne encephalitis: One vaccine protects against multiple flaviviruses Prior exposure to tick-borne encephalitis virus confers immunity to distinct, but genetically related, significant human pathogens. The tick-borne encephalitis complex comprises multiple ‘flaviviruses’; however, a licensed vaccine only exists for one: tick-borne encephalitis virus (TBEV). Alexander McAuley, of the University of Texas Medical Branch, USA, and collaborators tested human serum samples from donors who had either received the TBEV vaccine, been infected with the virus naturally, or had contracted the virus despite prior vaccination. The team tested the sera against six genetically related flaviviruses, looking for antibodies that indicate viral immunity. The results showed that TBEV exposure induce production of antibodies that inhibit other flaviviruses, the efficacy of which decreases as the genetic variation from TBEV increases. Additionally, sera from infected individuals generated more antibodies than sera from vaccinated donors. This study provides an insight into the relationship between genetic similarity and vaccine cross-protection.
format	article
author	Alexander J. McAuley Bevan Sawatsky Thomas Ksiazek Maricela Torres Miša Korva Stanka Lotrič-Furlan Tatjana Avšič-Županc Veronika von Messling Michael R. Holbrook Alexander N. Freiberg David W. C. Beasley Dennis A. Bente
author_facet	Alexander J. McAuley Bevan Sawatsky Thomas Ksiazek Maricela Torres Miša Korva Stanka Lotrič-Furlan Tatjana Avšič-Županc Veronika von Messling Michael R. Holbrook Alexander N. Freiberg David W. C. Beasley Dennis A. Bente
author_sort	Alexander J. McAuley
title	Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
title_short	Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
title_full	Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
title_fullStr	Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
title_full_unstemmed	Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
title_sort	cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a72ff5e911e648228cdfd515419ac629
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Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

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