Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia

Abstract Acute respiratory infections appear to precipitate vascular events. Acute myocardial infarction (AMI) and stroke are the leading cause of death and disability globally. This study was based on a cohort of patients admitted to Townsville University Hospital between January 2006 and December...

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Autores principales:	A. Pak, D. P. Eisen, E. S. McBryde, O. A. Adegboye
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a7303505a96842a798c0f3353ad76dd2
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spelling	oai:doaj.org-article:a7303505a96842a798c0f3353ad76dd22021-12-02T11:45:04ZHospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia10.1038/s41598-021-86301-32045-2322https://doaj.org/article/a7303505a96842a798c0f3353ad76dd22021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86301-3https://doaj.org/toc/2045-2322Abstract Acute respiratory infections appear to precipitate vascular events. Acute myocardial infarction (AMI) and stroke are the leading cause of death and disability globally. This study was based on a cohort of patients admitted to Townsville University Hospital between January 2006 and December 2016. Using a self-controlled case series design, we investigated the risk of AMI or ischaemic stroke after an episode of pneumonia. We defined the ‘risk interval’ as the first 14 days after hospitalisation for pneumonia and the ‘control interval’ as one year before and one year after the risk interval. Among a population (N = 4557) with a median age of over 70, a total of 128 AMI and 27 stroke cases were identified within 1 year of an episode of pneumonia in this study. Ten and two admissions occurred during the risk interval, while 118 and 25 admissions occurred during the control period. The relative incidence ratios (RIR) of AMI increased after an episode of pneumonia (RIR=4.85, 95% confidence interval (CI) 2.44–9.67). The risk for stroke after the exposure period of 14 days was 4.94 (95% CI 1.12–21.78) considering only the first stroke incidence. The RIR results for AMI and stroke were not altered by adjusting for age, sex or Indigenous status. The risk of AMI and stroke were significantly higher two weeks after an episode of pneumonia.A. PakD. P. EisenE. S. McBrydeO. A. AdegboyeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Pak D. P. Eisen E. S. McBryde O. A. Adegboye Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia
description	Abstract Acute respiratory infections appear to precipitate vascular events. Acute myocardial infarction (AMI) and stroke are the leading cause of death and disability globally. This study was based on a cohort of patients admitted to Townsville University Hospital between January 2006 and December 2016. Using a self-controlled case series design, we investigated the risk of AMI or ischaemic stroke after an episode of pneumonia. We defined the ‘risk interval’ as the first 14 days after hospitalisation for pneumonia and the ‘control interval’ as one year before and one year after the risk interval. Among a population (N = 4557) with a median age of over 70, a total of 128 AMI and 27 stroke cases were identified within 1 year of an episode of pneumonia in this study. Ten and two admissions occurred during the risk interval, while 118 and 25 admissions occurred during the control period. The relative incidence ratios (RIR) of AMI increased after an episode of pneumonia (RIR=4.85, 95% confidence interval (CI) 2.44–9.67). The risk for stroke after the exposure period of 14 days was 4.94 (95% CI 1.12–21.78) considering only the first stroke incidence. The RIR results for AMI and stroke were not altered by adjusting for age, sex or Indigenous status. The risk of AMI and stroke were significantly higher two weeks after an episode of pneumonia.
format	article
author	A. Pak D. P. Eisen E. S. McBryde O. A. Adegboye
author_facet	A. Pak D. P. Eisen E. S. McBryde O. A. Adegboye
author_sort	A. Pak
title	Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia
title_short	Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia
title_full	Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia
title_fullStr	Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia
title_full_unstemmed	Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia
title_sort	hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical northern australia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7303505a96842a798c0f3353ad76dd2
work_keys_str_mv	AT apak hospitalisationforlowerrespiratorytractinfectionisassociatedwithanincreasedincidenceofacutemyocardialinfarctionandstrokeintropicalnorthernaustralia AT dpeisen hospitalisationforlowerrespiratorytractinfectionisassociatedwithanincreasedincidenceofacutemyocardialinfarctionandstrokeintropicalnorthernaustralia AT esmcbryde hospitalisationforlowerrespiratorytractinfectionisassociatedwithanincreasedincidenceofacutemyocardialinfarctionandstrokeintropicalnorthernaustralia AT oaadegboye hospitalisationforlowerrespiratorytractinfectionisassociatedwithanincreasedincidenceofacutemyocardialinfarctionandstrokeintropicalnorthernaustralia
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Hospitalisation for lower respiratory tract infection is associated with an increased incidence of acute myocardial infarction and stroke in tropical Northern Australia

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