EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA

The aim of this study was to evaluate a possible role of AID (AICDA – activation-induced (cytidine) deaminase) in the bronchial asthma (BA) pathogenesis. Materials and methods. We have examined twelve healthy control persons, forty-two patients with allergic bronchial asthma (ABA) and twenty-seven p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	V. N. Mineev, M. A. Nyoma, L. N. Sorokina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	mrna activation-induced (cytidine) deaminase bronchial asthma lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a7305f2f8c254f24aadc7842ab04ded8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a7305f2f8c254f24aadc7842ab04ded8
record_format	dspace
spelling	oai:doaj.org-article:a7305f2f8c254f24aadc7842ab04ded82021-11-18T08:03:44ZEXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA1563-06252313-741X10.15789/1563-0625-2015-1-71-74https://doaj.org/article/a7305f2f8c254f24aadc7842ab04ded82015-03-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/810https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of this study was to evaluate a possible role of AID (AICDA – activation-induced (cytidine) deaminase) in the bronchial asthma (BA) pathogenesis. Materials and methods. We have examined twelve healthy control persons, forty-two patients with allergic bronchial asthma (ABA) and twenty-seven patients with non-allergic bronchial asthma (NABA). The AID mRNA expression was evaluated by means of RT-PCR. Results: AID mRNA was more significantly expressed in BA, than in healthy controls. Meanwhile, no significant differences were revealed between ABA and NABA groups. Correlation analysis of AID mRNA expression levels in peripheral blood lymphocytes has shown that CHε mRNA and total serum IgE revealed significant negative correlation, in the NABA group only. The levels of AID mRNA expression in peripheral blood lymphocytes exhibited positive and significant correlations with clinical characteristics, reflecting severity and stage of the disease, in BA patients. Moreover, a significant positive correlation was revealed with eosinophil contents in sputum. Conclusion. It was concluded that normal regulation of IgE class switching normally based on feedback regulation, was impaired in ABA but not affected in NABA.V. N. MineevM. A. NyomaL. N. SorokinaSPb RAACIarticlemrnaactivation-induced (cytidine) deaminasebronchial asthmalymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 1, Pp 71-74 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	mrna activation-induced (cytidine) deaminase bronchial asthma lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	mrna activation-induced (cytidine) deaminase bronchial asthma lymphocytes Immunologic diseases. Allergy RC581-607 V. N. Mineev M. A. Nyoma L. N. Sorokina EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
description	The aim of this study was to evaluate a possible role of AID (AICDA – activation-induced (cytidine) deaminase) in the bronchial asthma (BA) pathogenesis. Materials and methods. We have examined twelve healthy control persons, forty-two patients with allergic bronchial asthma (ABA) and twenty-seven patients with non-allergic bronchial asthma (NABA). The AID mRNA expression was evaluated by means of RT-PCR. Results: AID mRNA was more significantly expressed in BA, than in healthy controls. Meanwhile, no significant differences were revealed between ABA and NABA groups. Correlation analysis of AID mRNA expression levels in peripheral blood lymphocytes has shown that CHε mRNA and total serum IgE revealed significant negative correlation, in the NABA group only. The levels of AID mRNA expression in peripheral blood lymphocytes exhibited positive and significant correlations with clinical characteristics, reflecting severity and stage of the disease, in BA patients. Moreover, a significant positive correlation was revealed with eosinophil contents in sputum. Conclusion. It was concluded that normal regulation of IgE class switching normally based on feedback regulation, was impaired in ABA but not affected in NABA.
format	article
author	V. N. Mineev M. A. Nyoma L. N. Sorokina
author_facet	V. N. Mineev M. A. Nyoma L. N. Sorokina
author_sort	V. N. Mineev
title	EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
title_short	EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
title_full	EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
title_fullStr	EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
title_full_unstemmed	EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
title_sort	expression of aid-specific mrna in peripheral blood lymphocytes in bronchial asthma
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/a7305f2f8c254f24aadc7842ab04ded8
work_keys_str_mv	AT vnmineev expressionofaidspecificmrnainperipheralbloodlymphocytesinbronchialasthma AT manyoma expressionofaidspecificmrnainperipheralbloodlymphocytesinbronchialasthma AT lnsorokina expressionofaidspecificmrnainperipheralbloodlymphocytesinbronchialasthma
_version_	1718422439994589184

EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA

Ejemplares similares