HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY

Numerous literature data indicate to gradual, but steady ageependent decrease of immunological reactivity in human organism, manifesting as a reduced ability to develop specific immune response, both of cellular and humoral type. Such negative trends result into increased proposition and frequency o...

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Autor principal:	V. A. Kozlov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	homeostatic proliferation immunodeficiency na ve t cells memory t cells apoptosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a731c8e1e4414c31abccee4b6d5c9150
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spelling	oai:doaj.org-article:a731c8e1e4414c31abccee4b6d5c91502021-11-18T08:03:44ZHOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY1563-06252313-741X10.15789/1563-0625-2014-5-403-408https://doaj.org/article/a731c8e1e4414c31abccee4b6d5c91502014-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/725https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XNumerous literature data indicate to gradual, but steady ageependent decrease of immunological reactivity in human organism, manifesting as a reduced ability to develop specific immune response, both of cellular and humoral type. Such negative trends result into increased proposition and frequency of various diseases, including cancer and autoimmune disorders. Finally, an age-associated immunodeficiency is developed even in normal organism, without clear background of specific disorders. The multicomponent mechanisms of such deficiency are not yet fully clarified. One may assume that, among these potentially leading mechanisms, a homeostatic proliferation may be of sufficient importance. This type of cell growth is shown to accompany any negative effects on the numbers of lymphocytes in the body. It manifests as a reduced ability of lymphocytes to recognize foreign antigens associated with a background increase of self-reactive cells.V. A. KozlovSPb RAACIarticlehomeostatic proliferationimmunodeficiencyna ve t cellsmemory t cellsapoptosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 5, Pp 403-408 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	homeostatic proliferation immunodeficiency na ve t cells memory t cells apoptosis Immunologic diseases. Allergy RC581-607
spellingShingle	homeostatic proliferation immunodeficiency na ve t cells memory t cells apoptosis Immunologic diseases. Allergy RC581-607 V. A. Kozlov HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY
description	Numerous literature data indicate to gradual, but steady ageependent decrease of immunological reactivity in human organism, manifesting as a reduced ability to develop specific immune response, both of cellular and humoral type. Such negative trends result into increased proposition and frequency of various diseases, including cancer and autoimmune disorders. Finally, an age-associated immunodeficiency is developed even in normal organism, without clear background of specific disorders. The multicomponent mechanisms of such deficiency are not yet fully clarified. One may assume that, among these potentially leading mechanisms, a homeostatic proliferation may be of sufficient importance. This type of cell growth is shown to accompany any negative effects on the numbers of lymphocytes in the body. It manifests as a reduced ability of lymphocytes to recognize foreign antigens associated with a background increase of self-reactive cells.
format	article
author	V. A. Kozlov
author_facet	V. A. Kozlov
author_sort	V. A. Kozlov
title	HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY
title_short	HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY
title_full	HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY
title_fullStr	HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY
title_full_unstemmed	HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY
title_sort	homeostatc proliferation as a basis for the inevitable formation of total immunodeficiency
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/a731c8e1e4414c31abccee4b6d5c9150
work_keys_str_mv	AT vakozlov homeostatcproliferationasabasisfortheinevitableformationoftotalimmunodeficiency
_version_	1718422440205352960

HOMEOSTATC PROLIFERATION AS A BASIS FOR THE INEVITABLE FORMATION OF TOTAL IMMUNODEFICIENCY

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