Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mil...

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Autores principales:	Fabiola de Oliveira Paes-Leme, Eliana M. Souza, Paulo Ricardo Oliveira Paes, Maderleine Geisa Gomes, Felipe Santos Muniz, Marco Túlio Gomes Campos, Renata Barbosa Peixoto, Patricia Donado Vaz de Melo, Marcio H. L. Arndt, Adriane Costa Val
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dogs cystatin C creatinine failure insufficiency illness Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/a733f313366a4cfe863419223499d0c9
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spelling	oai:doaj.org-article:a733f313366a4cfe863419223499d0c92021-11-08T08:01:10ZCystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog2297-176910.3389/fvets.2021.721845https://doaj.org/article/a733f313366a4cfe863419223499d0c92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fvets.2021.721845/fullhttps://doaj.org/toc/2297-1769Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients' dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs.Fabiola de Oliveira Paes-LemeEliana M. SouzaPaulo Ricardo Oliveira PaesMaderleine Geisa GomesFelipe Santos MunizMarco Túlio Gomes CamposRenata Barbosa PeixotoPatricia Donado Vaz de MeloMarcio H. L. ArndtAdriane Costa ValFrontiers Media S.A.articledogscystatin CcreatininefailureinsufficiencyillnessVeterinary medicineSF600-1100ENFrontiers in Veterinary Science, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dogs cystatin C creatinine failure insufficiency illness Veterinary medicine SF600-1100
spellingShingle	dogs cystatin C creatinine failure insufficiency illness Veterinary medicine SF600-1100 Fabiola de Oliveira Paes-Leme Eliana M. Souza Paulo Ricardo Oliveira Paes Maderleine Geisa Gomes Felipe Santos Muniz Marco Túlio Gomes Campos Renata Barbosa Peixoto Patricia Donado Vaz de Melo Marcio H. L. Arndt Adriane Costa Val Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog
description	Critically ill hospitalized dogs are subject to certain complications, being acute kidney injury (AKI) a common one. Early diagnosis is crucial, and Cystatin C (CysC) is a reliable and early biomarker. The International Society of Renal Interest (IRIS) states that AKI severity can be assessed by mild changes in creatinine serum levels or reduction of urine output that cannot be considered biomarkers of renal injury but failure or insufficiency. Twenty-eight dogs admitted to the Intensive Care Unit under risk factors for the development of AKI were evaluated. Blood samples were collected for determination of sCr and CysC at admission and after 24, 48, and 72 h. Urine output was measured by daily monitoring, measured by collection in a closed system. The results showed the incidence of AKI was 67.9% based on the IRIS criteria and 78.6% based on cystatin C in critically ill patients' dogs. The measurement of serum cystatin C immediately on admission to the ICU was superior in the early identification of patients with AKI when compared to the IRIS classification and serum creatinine in critically ill dogs.
format	article
author	Fabiola de Oliveira Paes-Leme Eliana M. Souza Paulo Ricardo Oliveira Paes Maderleine Geisa Gomes Felipe Santos Muniz Marco Túlio Gomes Campos Renata Barbosa Peixoto Patricia Donado Vaz de Melo Marcio H. L. Arndt Adriane Costa Val
author_facet	Fabiola de Oliveira Paes-Leme Eliana M. Souza Paulo Ricardo Oliveira Paes Maderleine Geisa Gomes Felipe Santos Muniz Marco Túlio Gomes Campos Renata Barbosa Peixoto Patricia Donado Vaz de Melo Marcio H. L. Arndt Adriane Costa Val
author_sort	Fabiola de Oliveira Paes-Leme
title	Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog
title_short	Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog
title_full	Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog
title_fullStr	Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog
title_full_unstemmed	Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog
title_sort	cystatin c and iris: advances in the evaluation of kidney function in critically ill dog
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a733f313366a4cfe863419223499d0c9
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Cystatin C and Iris: Advances in the Evaluation of Kidney Function in Critically Ill Dog

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