CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

Helminth infections are associated with a reduction in inflammatory pathology in rodent models of type 1 diabetes. Here, the authors show patient data and that trehalose (produced by H. polygyrus) can alter the microbiome of mice, inducing regulatory CD8+ T cells and reducing susceptibility to autoi...

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Autores principales:	Chikako Shimokawa, Tamotsu Kato, Tadashi Takeuchi, Noriyasu Ohshima, Takao Furuki, Yoshiaki Ohtsu, Kazutomo Suzue, Takashi Imai, Seiji Obi, Alex Olia, Takashi Izumi, Minoru Sakurai, Hirokazu Arakawa, Hiroshi Ohno, Hajime Hisaeda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a73704cfcc8e40e2829fa49bad1879b2
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spelling	oai:doaj.org-article:a73704cfcc8e40e2829fa49bad1879b22021-12-02T15:34:36ZCD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes10.1038/s41467-020-15857-x2041-1723https://doaj.org/article/a73704cfcc8e40e2829fa49bad1879b22020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15857-xhttps://doaj.org/toc/2041-1723Helminth infections are associated with a reduction in inflammatory pathology in rodent models of type 1 diabetes. Here, the authors show patient data and that trehalose (produced by H. polygyrus) can alter the microbiome of mice, inducing regulatory CD8+ T cells and reducing susceptibility to autoimmune diabetes.Chikako ShimokawaTamotsu KatoTadashi TakeuchiNoriyasu OhshimaTakao FurukiYoshiaki OhtsuKazutomo SuzueTakashi ImaiSeiji ObiAlex OliaTakashi IzumiMinoru SakuraiHirokazu ArakawaHiroshi OhnoHajime HisaedaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chikako Shimokawa Tamotsu Kato Tadashi Takeuchi Noriyasu Ohshima Takao Furuki Yoshiaki Ohtsu Kazutomo Suzue Takashi Imai Seiji Obi Alex Olia Takashi Izumi Minoru Sakurai Hirokazu Arakawa Hiroshi Ohno Hajime Hisaeda CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes
description	Helminth infections are associated with a reduction in inflammatory pathology in rodent models of type 1 diabetes. Here, the authors show patient data and that trehalose (produced by H. polygyrus) can alter the microbiome of mice, inducing regulatory CD8+ T cells and reducing susceptibility to autoimmune diabetes.
format	article
author	Chikako Shimokawa Tamotsu Kato Tadashi Takeuchi Noriyasu Ohshima Takao Furuki Yoshiaki Ohtsu Kazutomo Suzue Takashi Imai Seiji Obi Alex Olia Takashi Izumi Minoru Sakurai Hirokazu Arakawa Hiroshi Ohno Hajime Hisaeda
author_facet	Chikako Shimokawa Tamotsu Kato Tadashi Takeuchi Noriyasu Ohshima Takao Furuki Yoshiaki Ohtsu Kazutomo Suzue Takashi Imai Seiji Obi Alex Olia Takashi Izumi Minoru Sakurai Hirokazu Arakawa Hiroshi Ohno Hajime Hisaeda
author_sort	Chikako Shimokawa
title	CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes
title_short	CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes
title_full	CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes
title_fullStr	CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes
title_full_unstemmed	CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes
title_sort	cd8+ regulatory t cells are critical in prevention of autoimmune-mediated diabetes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a73704cfcc8e40e2829fa49bad1879b2
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CD8+ regulatory T cells are critical in prevention of autoimmune-mediated diabetes

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