DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity

Abstract It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psych...

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Autores principales:	Rajendran Ramesh, Aparna Sundaresh, Ravi Philip Rajkumar, Vir Singh Negi, M. A. Vijayalakshmi, Rajagopal Krishnamoorthy, Ryad Tamouza, Marion Leboyer, A. S. Kamalanathan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/a73844f9cf9e4529849057be02e8e7dd
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spelling	oai:doaj.org-article:a73844f9cf9e4529849057be02e8e7dd2021-12-02T13:33:05ZDNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity10.1038/s41537-021-00143-62334-265Xhttps://doaj.org/article/a73844f9cf9e4529849057be02e8e7dd2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00143-6https://doaj.org/toc/2334-265XAbstract It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients.Rajendran RameshAparna SundareshRavi Philip RajkumarVir Singh NegiM. A. VijayalakshmiRajagopal KrishnamoorthyRyad TamouzaMarion LeboyerA. S. KamalanathanNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Rajendran Ramesh Aparna Sundaresh Ravi Philip Rajkumar Vir Singh Negi M. A. Vijayalakshmi Rajagopal Krishnamoorthy Ryad Tamouza Marion Leboyer A. S. Kamalanathan DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
description	Abstract It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients.
format	article
author	Rajendran Ramesh Aparna Sundaresh Ravi Philip Rajkumar Vir Singh Negi M. A. Vijayalakshmi Rajagopal Krishnamoorthy Ryad Tamouza Marion Leboyer A. S. Kamalanathan
author_facet	Rajendran Ramesh Aparna Sundaresh Ravi Philip Rajkumar Vir Singh Negi M. A. Vijayalakshmi Rajagopal Krishnamoorthy Ryad Tamouza Marion Leboyer A. S. Kamalanathan
author_sort	Rajendran Ramesh
title	DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
title_short	DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
title_full	DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
title_fullStr	DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
title_full_unstemmed	DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity
title_sort	dna hydrolysing igg catalytic antibodies: an emerging link between psychoses and autoimmunity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a73844f9cf9e4529849057be02e8e7dd
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DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity

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