A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine

A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine

Human leukocyte antigen (<i>HLA</i>) encoded by the <i>HLA</i> gene is an important modulator for immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of <i>HLA</i> vary widely at population level and are responsible for developing s...

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Autores principales: Chiraphat Kloypan, Napatrupron Koomdee, Patompong Satapornpong, Therdpong Tempark, Mohitosh Biswas, Chonlaphat Sukasem
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
human leukocyte antigen
<i>HLA</i> genetic polymorphisms
SCARs
pharmacogenomics
precision medicine
Medicine
R
Pharmacy and materia medica
RS1-441
Acceso en línea:https://doaj.org/article/a73aaaba377c4b0ebe02f1345961e5ca
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spelling oai:doaj.org-article:a73aaaba377c4b0ebe02f1345961e5ca2021-11-25T18:39:09ZA Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine10.3390/ph141110771424-8247https://doaj.org/article/a73aaaba377c4b0ebe02f1345961e5ca2021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1077https://doaj.org/toc/1424-8247Human leukocyte antigen (<i>HLA</i>) encoded by the <i>HLA</i> gene is an important modulator for immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of <i>HLA</i> vary widely at population level and are responsible for developing severe cutaneous adverse drug reactions (SCARs) such as Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), maculopapular exanthema (MPE). The associations of different <i>HLA</i> alleles with the risk of drug induced SJS/TEN, DRESS and MPE are strongly supportive for clinical considerations. Prescribing guidelines generated by different national and international working groups for translation of <i>HLA</i> pharmacogenetics into clinical practice are underway and functional in many countries, including Thailand. Cutting edge genomic technologies may accelerate wider adoption of <i>HLA</i> screening in routine clinical settings. There are great opportunities and several challenges as well for effective implementation of <i>HLA</i> genotyping globally in routine clinical practice for the prevention of drug induced SCARs substantially, enforcing precision medicine initiatives.Chiraphat KloypanNapatrupron KoomdeePatompong SatapornpongTherdpong TemparkMohitosh BiswasChonlaphat SukasemMDPI AGarticlehuman leukocyte antigen<i>HLA</i> genetic polymorphismsSCARspharmacogenomicsprecision medicineMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1077, p 1077 (2021)
institution DOAJ
collection DOAJ
language EN
topic human leukocyte antigen
<i>HLA</i> genetic polymorphisms
SCARs
pharmacogenomics
precision medicine
Medicine
R
Pharmacy and materia medica
RS1-441
spellingShingle human leukocyte antigen
<i>HLA</i> genetic polymorphisms
SCARs
pharmacogenomics
precision medicine
Medicine
R
Pharmacy and materia medica
RS1-441
Chiraphat Kloypan
Napatrupron Koomdee
Patompong Satapornpong
Therdpong Tempark
Mohitosh Biswas
Chonlaphat Sukasem
A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
description Human leukocyte antigen (<i>HLA</i>) encoded by the <i>HLA</i> gene is an important modulator for immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of <i>HLA</i> vary widely at population level and are responsible for developing severe cutaneous adverse drug reactions (SCARs) such as Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), maculopapular exanthema (MPE). The associations of different <i>HLA</i> alleles with the risk of drug induced SJS/TEN, DRESS and MPE are strongly supportive for clinical considerations. Prescribing guidelines generated by different national and international working groups for translation of <i>HLA</i> pharmacogenetics into clinical practice are underway and functional in many countries, including Thailand. Cutting edge genomic technologies may accelerate wider adoption of <i>HLA</i> screening in routine clinical settings. There are great opportunities and several challenges as well for effective implementation of <i>HLA</i> genotyping globally in routine clinical practice for the prevention of drug induced SCARs substantially, enforcing precision medicine initiatives.
format article
author Chiraphat Kloypan
Napatrupron Koomdee
Patompong Satapornpong
Therdpong Tempark
Mohitosh Biswas
Chonlaphat Sukasem
author_facet Chiraphat Kloypan
Napatrupron Koomdee
Patompong Satapornpong
Therdpong Tempark
Mohitosh Biswas
Chonlaphat Sukasem
author_sort Chiraphat Kloypan
title A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
title_short A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
title_full A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
title_fullStr A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
title_full_unstemmed A Comprehensive Review of <i>HLA</i> and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine
title_sort comprehensive review of <i>hla</i> and severe cutaneous adverse drug reactions: implication for clinical pharmacogenomics and precision medicine
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/a73aaaba377c4b0ebe02f1345961e5ca
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