A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer

Improved therapeutics are needed for treating breast cancer. Here they show the druggability of myoferlin with a small molecule inhibitor in breast cancer and demonstrate its anti-breast cancer effects in vitro and in vivo.

Guardado en:
Detalles Bibliográficos
Autores principales: Tao Zhang, Jingjie Li, Yuan He, Feifei Yang, Yun Hao, Wangrui Jin, Jing Wu, Zhenliang Sun, Yunqi Li, Yihua Chen, Zhengfang Yi, Mingyao Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/a73b563276a4425294fa01eeae77ed30
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a73b563276a4425294fa01eeae77ed30
record_format dspace
spelling oai:doaj.org-article:a73b563276a4425294fa01eeae77ed302021-12-02T16:50:10ZA small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer10.1038/s41467-018-06179-02041-1723https://doaj.org/article/a73b563276a4425294fa01eeae77ed302018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06179-0https://doaj.org/toc/2041-1723Improved therapeutics are needed for treating breast cancer. Here they show the druggability of myoferlin with a small molecule inhibitor in breast cancer and demonstrate its anti-breast cancer effects in vitro and in vivo.Tao ZhangJingjie LiYuan HeFeifei YangYun HaoWangrui JinJing WuZhenliang SunYunqi LiYihua ChenZhengfang YiMingyao LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tao Zhang
Jingjie Li
Yuan He
Feifei Yang
Yun Hao
Wangrui Jin
Jing Wu
Zhenliang Sun
Yunqi Li
Yihua Chen
Zhengfang Yi
Mingyao Liu
A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
description Improved therapeutics are needed for treating breast cancer. Here they show the druggability of myoferlin with a small molecule inhibitor in breast cancer and demonstrate its anti-breast cancer effects in vitro and in vivo.
format article
author Tao Zhang
Jingjie Li
Yuan He
Feifei Yang
Yun Hao
Wangrui Jin
Jing Wu
Zhenliang Sun
Yunqi Li
Yihua Chen
Zhengfang Yi
Mingyao Liu
author_facet Tao Zhang
Jingjie Li
Yuan He
Feifei Yang
Yun Hao
Wangrui Jin
Jing Wu
Zhenliang Sun
Yunqi Li
Yihua Chen
Zhengfang Yi
Mingyao Liu
author_sort Tao Zhang
title A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
title_short A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
title_full A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
title_fullStr A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
title_full_unstemmed A small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
title_sort small molecule targeting myoferlin exerts promising anti-tumor effects on breast cancer
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/a73b563276a4425294fa01eeae77ed30
work_keys_str_mv AT taozhang asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT jingjieli asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yuanhe asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT feifeiyang asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yunhao asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT wangruijin asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT jingwu asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT zhenliangsun asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yunqili asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yihuachen asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT zhengfangyi asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT mingyaoliu asmallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT taozhang smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT jingjieli smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yuanhe smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT feifeiyang smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yunhao smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT wangruijin smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT jingwu smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT zhenliangsun smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yunqili smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT yihuachen smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT zhengfangyi smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
AT mingyaoliu smallmoleculetargetingmyoferlinexertspromisingantitumoreffectsonbreastcancer
_version_ 1718383117482328064