Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations

To limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hierarchically differentiating tissues can approach th...

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Auteurs principaux:	Imre Derényi, Gergely J. Szöllősi
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/a73bfd5d10674b91ad5f4d27c0ecfe16
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id	oai:doaj.org-article:a73bfd5d10674b91ad5f4d27c0ecfe16
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spelling	oai:doaj.org-article:a73bfd5d10674b91ad5f4d27c0ecfe162021-12-02T15:38:44ZHierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations10.1038/ncomms145452041-1723https://doaj.org/article/a73bfd5d10674b91ad5f4d27c0ecfe162017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14545https://doaj.org/toc/2041-1723To limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hierarchically differentiating tissues can approach this limit, and that this depends on uneven divisional rates across the hierarchy.Imre DerényiGergely J. SzöllősiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Imre Derényi Gergely J. Szöllősi Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
description	To limit the accumulation of somatic mutations, renewing tissues must minimize the number of times each cell divides during differentiation. Here, the authors analytically derive the lower limit of lifetime divisional load of a tissue, show that hierarchically differentiating tissues can approach this limit, and that this depends on uneven divisional rates across the hierarchy.
format	article
author	Imre Derényi Gergely J. Szöllősi
author_facet	Imre Derényi Gergely J. Szöllősi
author_sort	Imre Derényi
title	Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_short	Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_full	Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_fullStr	Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_full_unstemmed	Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
title_sort	hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a73bfd5d10674b91ad5f4d27c0ecfe16
work_keys_str_mv	AT imrederenyi hierarchicaltissueorganizationasageneralmechanismtolimittheaccumulationofsomaticmutations AT gergelyjszollosi hierarchicaltissueorganizationasageneralmechanismtolimittheaccumulationofsomaticmutations
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Hierarchical tissue organization as a general mechanism to limit the accumulation of somatic mutations

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