The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting peptides, the authors show evidence of immuno...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/a73e02cb910a4f8c83a017a74a1f0a13 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:a73e02cb910a4f8c83a017a74a1f0a13 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:a73e02cb910a4f8c83a017a74a1f0a132021-12-02T18:14:16ZThe shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution10.1038/s41467-020-18514-52041-1723https://doaj.org/article/a73e02cb910a4f8c83a017a74a1f0a132020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18514-5https://doaj.org/toc/2041-1723DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting peptides, the authors show evidence of immunoediting in MMR-deficient colorectal and endometrial cancers.Alexej BallhausenMoritz Jakob PrzybillaMichael JendruschSaskia HauptElisabeth PfaffendorfFlorian SeidlerJohannes WittAlejandro Hernandez SanchezKatharina UrbanMarkus DraxlbauerSonja KrausertAysel AhadovaMartin Simon KalteisPauline L. PfudererDaniel HeidDamian StichelJohannes GebertMaria BonsackSarah SchottHendrik BläkerToni SeppäläJukka-Pekka MecklinSanne Ten BroekeMaartje NielsenVincent HeuvelineJulia KrzykallaAxel BennerAngelika Beate RiemerMagnus von Knebel DoeberitzMatthias KloorNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Alexej Ballhausen Moritz Jakob Przybilla Michael Jendrusch Saskia Haupt Elisabeth Pfaffendorf Florian Seidler Johannes Witt Alejandro Hernandez Sanchez Katharina Urban Markus Draxlbauer Sonja Krausert Aysel Ahadova Martin Simon Kalteis Pauline L. Pfuderer Daniel Heid Damian Stichel Johannes Gebert Maria Bonsack Sarah Schott Hendrik Bläker Toni Seppälä Jukka-Pekka Mecklin Sanne Ten Broeke Maartje Nielsen Vincent Heuveline Julia Krzykalla Axel Benner Angelika Beate Riemer Magnus von Knebel Doeberitz Matthias Kloor The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution |
| description |
DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting peptides, the authors show evidence of immunoediting in MMR-deficient colorectal and endometrial cancers. |
| format |
article |
| author |
Alexej Ballhausen Moritz Jakob Przybilla Michael Jendrusch Saskia Haupt Elisabeth Pfaffendorf Florian Seidler Johannes Witt Alejandro Hernandez Sanchez Katharina Urban Markus Draxlbauer Sonja Krausert Aysel Ahadova Martin Simon Kalteis Pauline L. Pfuderer Daniel Heid Damian Stichel Johannes Gebert Maria Bonsack Sarah Schott Hendrik Bläker Toni Seppälä Jukka-Pekka Mecklin Sanne Ten Broeke Maartje Nielsen Vincent Heuveline Julia Krzykalla Axel Benner Angelika Beate Riemer Magnus von Knebel Doeberitz Matthias Kloor |
| author_facet |
Alexej Ballhausen Moritz Jakob Przybilla Michael Jendrusch Saskia Haupt Elisabeth Pfaffendorf Florian Seidler Johannes Witt Alejandro Hernandez Sanchez Katharina Urban Markus Draxlbauer Sonja Krausert Aysel Ahadova Martin Simon Kalteis Pauline L. Pfuderer Daniel Heid Damian Stichel Johannes Gebert Maria Bonsack Sarah Schott Hendrik Bläker Toni Seppälä Jukka-Pekka Mecklin Sanne Ten Broeke Maartje Nielsen Vincent Heuveline Julia Krzykalla Axel Benner Angelika Beate Riemer Magnus von Knebel Doeberitz Matthias Kloor |
| author_sort |
Alexej Ballhausen |
| title |
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution |
| title_short |
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution |
| title_full |
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution |
| title_fullStr |
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution |
| title_full_unstemmed |
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution |
| title_sort |
shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/a73e02cb910a4f8c83a017a74a1f0a13 |
| work_keys_str_mv |
AT alexejballhausen thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT moritzjakobprzybilla thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT michaeljendrusch thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT saskiahaupt thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT elisabethpfaffendorf thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT florianseidler thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT johanneswitt thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT alejandrohernandezsanchez thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT katharinaurban thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT markusdraxlbauer thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT sonjakrausert thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT ayselahadova thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT martinsimonkalteis thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT paulinelpfuderer thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT danielheid thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT damianstichel thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT johannesgebert thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT mariabonsack thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT sarahschott thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT hendrikblaker thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT toniseppala thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT jukkapekkamecklin thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT sannetenbroeke thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT maartjenielsen thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT vincentheuveline thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT juliakrzykalla thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT axelbenner thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT angelikabeateriemer thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT magnusvonknebeldoeberitz thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT matthiaskloor thesharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT alexejballhausen sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT moritzjakobprzybilla sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT michaeljendrusch sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT saskiahaupt sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT elisabethpfaffendorf sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT florianseidler sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT johanneswitt sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT alejandrohernandezsanchez sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT katharinaurban sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT markusdraxlbauer sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT sonjakrausert sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT ayselahadova sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT martinsimonkalteis sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT paulinelpfuderer sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT danielheid sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT damianstichel sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT johannesgebert sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT mariabonsack sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT sarahschott sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT hendrikblaker sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT toniseppala sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT jukkapekkamecklin sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT sannetenbroeke sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT maartjenielsen sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT vincentheuveline sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT juliakrzykalla sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT axelbenner sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT angelikabeateriemer sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT magnusvonknebeldoeberitz sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution AT matthiaskloor sharedframeshiftmutationlandscapeofmicrosatelliteunstablecancerssuggestsimmunoeditingduringtumorevolution |
| _version_ |
1718378412151668736 |