The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain

The human PAXT complex and the MTREC complex in fission yeast are important exosome cofactors, serving in the degradation of specific noncoding RNAs. Here, the authors combine structural, biochemical and in vivo methods to show how Red1 recruits the Mtl1 helicase by an interface not seen before in h...

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Autores principales:	Nikolay Dobrev, Yasar Luqman Ahmed, Anusree Sivadas, Komal Soni, Tamás Fischer, Irmgard Sinning
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a741735b27b946b7bd59c8534c1eb5c6
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spelling	oai:doaj.org-article:a741735b27b946b7bd59c8534c1eb5c62021-12-02T17:47:34ZThe zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain10.1038/s41467-021-23565-32041-1723https://doaj.org/article/a741735b27b946b7bd59c8534c1eb5c62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23565-3https://doaj.org/toc/2041-1723The human PAXT complex and the MTREC complex in fission yeast are important exosome cofactors, serving in the degradation of specific noncoding RNAs. Here, the authors combine structural, biochemical and in vivo methods to show how Red1 recruits the Mtl1 helicase by an interface not seen before in helicase-adaptor complexes.Nikolay DobrevYasar Luqman AhmedAnusree SivadasKomal SoniTamás FischerIrmgard SinningNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolay Dobrev Yasar Luqman Ahmed Anusree Sivadas Komal Soni Tamás Fischer Irmgard Sinning The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
description	The human PAXT complex and the MTREC complex in fission yeast are important exosome cofactors, serving in the degradation of specific noncoding RNAs. Here, the authors combine structural, biochemical and in vivo methods to show how Red1 recruits the Mtl1 helicase by an interface not seen before in helicase-adaptor complexes.
format	article
author	Nikolay Dobrev Yasar Luqman Ahmed Anusree Sivadas Komal Soni Tamás Fischer Irmgard Sinning
author_facet	Nikolay Dobrev Yasar Luqman Ahmed Anusree Sivadas Komal Soni Tamás Fischer Irmgard Sinning
author_sort	Nikolay Dobrev
title	The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_short	The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_full	The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_fullStr	The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_full_unstemmed	The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
title_sort	zinc-finger protein red1 orchestrates mtrec submodules and binds the mtl1 helicase arch domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a741735b27b946b7bd59c8534c1eb5c6
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The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain

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