The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents.
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Nature Portfolio
2018
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oai:doaj.org-article:a74b5c103f5b4b358a8a947c36ebe64a2021-12-02T15:33:54ZThe ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel10.1038/s41467-018-03728-52041-1723https://doaj.org/article/a74b5c103f5b4b358a8a947c36ebe64a2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03728-5https://doaj.org/toc/2041-1723Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents.Gabriele StephanLumei HuangYong TangSandra VilottiElsa FabbrettiYe YuWolfgang NörenbergHeike FrankeFlóra GölöncsérBeáta SperlághAnke DopychaiRalf HausmannGünther SchmalzingPatrizia RubiniPeter IllesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Gabriele Stephan Lumei Huang Yong Tang Sandra Vilotti Elsa Fabbretti Ye Yu Wolfgang Nörenberg Heike Franke Flóra Gölöncsér Beáta Sperlágh Anke Dopychai Ralf Hausmann Günther Schmalzing Patrizia Rubini Peter Illes The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| description |
Two subclasses of ligand-gated ion channels (ASIC3 and P2X3) are both present at sensory neurons and might be therefore subject to receptor crosstalk. Here authors use electrophysiology, biochemistry and co-immunoprecipitation to show that the two ion channels interact and affect P2X3 currents. |
| format |
article |
| author |
Gabriele Stephan Lumei Huang Yong Tang Sandra Vilotti Elsa Fabbretti Ye Yu Wolfgang Nörenberg Heike Franke Flóra Gölöncsér Beáta Sperlágh Anke Dopychai Ralf Hausmann Günther Schmalzing Patrizia Rubini Peter Illes |
| author_facet |
Gabriele Stephan Lumei Huang Yong Tang Sandra Vilotti Elsa Fabbretti Ye Yu Wolfgang Nörenberg Heike Franke Flóra Gölöncsér Beáta Sperlágh Anke Dopychai Ralf Hausmann Günther Schmalzing Patrizia Rubini Peter Illes |
| author_sort |
Gabriele Stephan |
| title |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_short |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_full |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_fullStr |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_full_unstemmed |
The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| title_sort |
asic3/p2x3 cognate receptor is a pain-relevant and ligand-gated cationic channel |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a74b5c103f5b4b358a8a947c36ebe64a |
| work_keys_str_mv |
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