A concise review of testosterone and bone health

Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lampur, Malaysia Abstract: Osteoporosis is a condition causing significant morbidity and mortality in the elderly population worldwide. Age-related testosteron...

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Autores principales:	Mohamad NV, Soelaiman IN, Chin KY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	androgen men osteopenia osteoporosis oestrogen skeleton Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a74c432244ed4f0abd76260a2582dc00
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spelling	oai:doaj.org-article:a74c432244ed4f0abd76260a2582dc002021-12-02T04:02:44ZA concise review of testosterone and bone health1178-1998https://doaj.org/article/a74c432244ed4f0abd76260a2582dc002016-09-01T00:00:00Zhttps://www.dovepress.com/a-concise-review-of-testosterone-and-bone-health-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lampur, Malaysia Abstract: Osteoporosis is a condition causing significant morbidity and mortality in the elderly population worldwide. Age-related testosterone deficiency is the most important factor of bone loss in elderly men. Androgen can influence bone health by binding to androgen receptors directly or to estrogen receptors (ERs) indirectly via aromatization to estrogen. This review summarized the direct and indirect effects of androgens on bone derived from in vitro, in vivo, and human studies. Cellular studies showed that androgen stimulated the proliferation of preosteoblasts and differentiation of osteoblasts. The converted estrogen suppressed osteoclast formation and resorption activity by blocking the receptor activator of nuclear factor κ-B ligand pathway. In animal studies, activation of androgen and ERα, but not ERβ, was shown to be important in acquisition and maintenance of bone mass. Human epidemiological studies demonstrated a significant relationship between estrogen and testosterone in bone mineral density and fracture risk, but the relative significance between the two remained debatable. Human experimental studies showed that estrogen was needed in suppressing bone resorption, but both androgen and estrogen were indispensable for bone formation. As a conclusion, maintaining optimal level of androgen is essential in preventing osteoporosis and its complications in elderly men. Keywords: androgen, men, osteopenia, osteoporosis, estrogen, skeletonMohamad NVSoelaiman INChin KYDove Medical PressarticleandrogenmenosteopeniaosteoporosisoestrogenskeletonGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1317-1324 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	androgen men osteopenia osteoporosis oestrogen skeleton Geriatrics RC952-954.6
spellingShingle	androgen men osteopenia osteoporosis oestrogen skeleton Geriatrics RC952-954.6 Mohamad NV Soelaiman IN Chin KY A concise review of testosterone and bone health
description	Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lampur, Malaysia Abstract: Osteoporosis is a condition causing significant morbidity and mortality in the elderly population worldwide. Age-related testosterone deficiency is the most important factor of bone loss in elderly men. Androgen can influence bone health by binding to androgen receptors directly or to estrogen receptors (ERs) indirectly via aromatization to estrogen. This review summarized the direct and indirect effects of androgens on bone derived from in vitro, in vivo, and human studies. Cellular studies showed that androgen stimulated the proliferation of preosteoblasts and differentiation of osteoblasts. The converted estrogen suppressed osteoclast formation and resorption activity by blocking the receptor activator of nuclear factor κ-B ligand pathway. In animal studies, activation of androgen and ERα, but not ERβ, was shown to be important in acquisition and maintenance of bone mass. Human epidemiological studies demonstrated a significant relationship between estrogen and testosterone in bone mineral density and fracture risk, but the relative significance between the two remained debatable. Human experimental studies showed that estrogen was needed in suppressing bone resorption, but both androgen and estrogen were indispensable for bone formation. As a conclusion, maintaining optimal level of androgen is essential in preventing osteoporosis and its complications in elderly men. Keywords: androgen, men, osteopenia, osteoporosis, estrogen, skeleton
format	article
author	Mohamad NV Soelaiman IN Chin KY
author_facet	Mohamad NV Soelaiman IN Chin KY
author_sort	Mohamad NV
title	A concise review of testosterone and bone health
title_short	A concise review of testosterone and bone health
title_full	A concise review of testosterone and bone health
title_fullStr	A concise review of testosterone and bone health
title_full_unstemmed	A concise review of testosterone and bone health
title_sort	concise review of testosterone and bone health
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a74c432244ed4f0abd76260a2582dc00
work_keys_str_mv	AT mohamadnv aconcisereviewoftestosteroneandbonehealth AT soelaimanin aconcisereviewoftestosteroneandbonehealth AT chinky aconcisereviewoftestosteroneandbonehealth AT mohamadnv concisereviewoftestosteroneandbonehealth AT soelaimanin concisereviewoftestosteroneandbonehealth AT chinky concisereviewoftestosteroneandbonehealth
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A concise review of testosterone and bone health

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