NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy

Ruifen Ge1,*, Jie Cao1,*, Jinnan Chi,1 Shangcong Han,1 Yan Liang,1 Lisa Xu,1 Mingtao Liang,2 Yong Sun11Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; 2Department of Pharmaceutics, School of Biomedical Science and Pharmacy, Universi...

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Autores principales:	Ge R, Cao J, Chi J, Han S, Liang Y, Xu L, Liang M, Sun Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Phototherapy Chemotherapy Combined therapy Dendrimer ICG derivatives Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a7538526e263445ca95a2d2f9eaab1a2
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spelling	oai:doaj.org-article:a7538526e263445ca95a2d2f9eaab1a22021-12-02T00:15:43ZNIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy1178-2013https://doaj.org/article/a7538526e263445ca95a2d2f9eaab1a22019-07-01T00:00:00Zhttps://www.dovepress.com/nir-guided-dendritic-nanoplatform-for-improving-antitumor-efficacy-by--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ruifen Ge1,, Jie Cao1,, Jinnan Chi,1 Shangcong Han,1 Yan Liang,1 Lisa Xu,1 Mingtao Liang,2 Yong Sun11Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; 2Department of Pharmaceutics, School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia*These authors contributed equally to this workBackground: Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is a promising noninvasive strategy in the treatment of cancers due to its highly localized specificity to tumors and minimal side effects to normal tissues. However, single phototherapy often causes tumor recurrence which hinders its clinical applications. Therefore, developing a NIR-guided dendritic nanoplatform for improving the phototherapy effect and reducing the recurrence of tumors by synergistic chemotherapy and phototherapy is essential.Methods: A fluorescent targeting ligand, insisting of ICG derivative cypate and a tumor penetration peptide iRGD (CRGDKGPDC), was covalently combined with PAMAM dendrimer to prepare a single agent-based dendritic theranostic nanoplatform iRGD-cypate-PAMAM-DTX (RCPD).Results: Compared with free cypate, the resulted RCPD could generate enhanced singlet oxygen species while maintaining its fluorescence intensity and heat generation ability when subjected to NIR irradiation. Furthermore, our in vitro and in vivo therapeutic studies demonstrated that compared with phototherapy or chemotherapy alone, the combinatorial chemo-photo treatment of RCPD with the local exposure of NIR light can significantly improve anti-tumor efficiency and reduce the risk of recurrence of tumors.Conclusion: The multifunctional theranostic platform (RCPD) could be used as a promising method for NIR fluorescence image-guided combinatorial treatment of tumor cancers.Keywords: phototherapy, chemotherapy, combined therapy, dendrimer, ICG derivativesGe RCao JChi JHan SLiang YXu LLiang MSun YDove Medical PressarticlePhototherapyChemotherapyCombined therapyDendrimerICG derivativesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4931-4947 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Phototherapy Chemotherapy Combined therapy Dendrimer ICG derivatives Medicine (General) R5-920
spellingShingle	Phototherapy Chemotherapy Combined therapy Dendrimer ICG derivatives Medicine (General) R5-920 Ge R Cao J Chi J Han S Liang Y Xu L Liang M Sun Y NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy
description	Ruifen Ge1,, Jie Cao1,, Jinnan Chi,1 Shangcong Han,1 Yan Liang,1 Lisa Xu,1 Mingtao Liang,2 Yong Sun11Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, People’s Republic of China; 2Department of Pharmaceutics, School of Biomedical Science and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia*These authors contributed equally to this workBackground: Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT), is a promising noninvasive strategy in the treatment of cancers due to its highly localized specificity to tumors and minimal side effects to normal tissues. However, single phototherapy often causes tumor recurrence which hinders its clinical applications. Therefore, developing a NIR-guided dendritic nanoplatform for improving the phototherapy effect and reducing the recurrence of tumors by synergistic chemotherapy and phototherapy is essential.Methods: A fluorescent targeting ligand, insisting of ICG derivative cypate and a tumor penetration peptide iRGD (CRGDKGPDC), was covalently combined with PAMAM dendrimer to prepare a single agent-based dendritic theranostic nanoplatform iRGD-cypate-PAMAM-DTX (RCPD).Results: Compared with free cypate, the resulted RCPD could generate enhanced singlet oxygen species while maintaining its fluorescence intensity and heat generation ability when subjected to NIR irradiation. Furthermore, our in vitro and in vivo therapeutic studies demonstrated that compared with phototherapy or chemotherapy alone, the combinatorial chemo-photo treatment of RCPD with the local exposure of NIR light can significantly improve anti-tumor efficiency and reduce the risk of recurrence of tumors.Conclusion: The multifunctional theranostic platform (RCPD) could be used as a promising method for NIR fluorescence image-guided combinatorial treatment of tumor cancers.Keywords: phototherapy, chemotherapy, combined therapy, dendrimer, ICG derivatives
format	article
author	Ge R Cao J Chi J Han S Liang Y Xu L Liang M Sun Y
author_facet	Ge R Cao J Chi J Han S Liang Y Xu L Liang M Sun Y
author_sort	Ge R
title	NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy
title_short	NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy
title_full	NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy
title_fullStr	NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy
title_full_unstemmed	NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy
title_sort	nir-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a7538526e263445ca95a2d2f9eaab1a2
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NIR-guided dendritic nanoplatform for improving antitumor efficacy by combining chemo-phototherapy

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