Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population

Sang Min Lee,1 Eunhee Ha,2 Jae-Hong Ryoo3 1Department of Psychiatry, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea; 2Department of Occupational and Environment Medicine, College of Medicine, Ewha Womans University, Seoul, Korea; 3Department of Occupationa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lee SM, Ha E, Ryoo JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	gamma-glutamyltransferase cerebral infarction stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a759569d3f2c4cfe97e8f050f8f72dd2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a759569d3f2c4cfe97e8f050f8f72dd2
record_format	dspace
spelling	oai:doaj.org-article:a759569d3f2c4cfe97e8f050f8f72dd22021-12-02T15:11:07ZSerum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population1178-2021https://doaj.org/article/a759569d3f2c4cfe97e8f050f8f72dd22021-08-01T00:00:00Zhttps://www.dovepress.com/serum-gamma-glutamyltransferase-levels-predict-the-development-of-cere-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Sang Min Lee,1 Eunhee Ha,2 Jae-Hong Ryoo3 1Department of Psychiatry, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea; 2Department of Occupational and Environment Medicine, College of Medicine, Ewha Womans University, Seoul, Korea; 3Department of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, Seoul, KoreaCorrespondence: Jae-Hong RyooDepartments of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, KoreaTel +82-10-6235-2208Fax +82-2-969-0792Email armani131@naver.comPurpose: This study examined the relationship between serum gamma-glutamyltransferase concentration and the risk of cerebral infarction in the Koreans.Materials and Methods: A total of 209,481 out of 223,551 participants in the National Health Information Database who received medical checkups in 2009 were included in the final analysis. The diagnosis code ICD I63 was used for identifying cerebral infarction cases and tracked the development of cerebral infarction by 2013. Cox proportional hazards model was used to calculate hazard ratios (HRs) for cerebral infarction and their confidence interval (CI).Results: During a follow-up period of 915,387.5 person-years, 2403 incident cases of cerebral infarction developed between 2009 and 2013. After adjusting for multiple covariates, the hazard ratios (95% confidence interval) for incident cerebral infarction, comparing the second, third, and fourth quartile of serum gamma-glutamyltransferase levels with the first quartile, were 1.11 (0.98– 1.27), 1.39 (1.22– 1.58), and 1.49 (1.29– 1.71), respectively (P for trend < 0.001).Conclusion: Elevated serum gamma-glutamyltransferase levels were independently associated with the future development of cerebral infarction in Koreans.Keywords: gamma-glutamyltransferase, cerebral infarction, strokeLee SMHa ERyoo JHDove Medical Pressarticlegamma-glutamyltransferasecerebral infarctionstrokeNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2749-2756 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gamma-glutamyltransferase cerebral infarction stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	gamma-glutamyltransferase cerebral infarction stroke Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lee SM Ha E Ryoo JH Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population
description	Sang Min Lee,1 Eunhee Ha,2 Jae-Hong Ryoo3 1Department of Psychiatry, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, Korea; 2Department of Occupational and Environment Medicine, College of Medicine, Ewha Womans University, Seoul, Korea; 3Department of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, Seoul, KoreaCorrespondence: Jae-Hong RyooDepartments of Occupational and Environmental Medicine, School of Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, KoreaTel +82-10-6235-2208Fax +82-2-969-0792Email armani131@naver.comPurpose: This study examined the relationship between serum gamma-glutamyltransferase concentration and the risk of cerebral infarction in the Koreans.Materials and Methods: A total of 209,481 out of 223,551 participants in the National Health Information Database who received medical checkups in 2009 were included in the final analysis. The diagnosis code ICD I63 was used for identifying cerebral infarction cases and tracked the development of cerebral infarction by 2013. Cox proportional hazards model was used to calculate hazard ratios (HRs) for cerebral infarction and their confidence interval (CI).Results: During a follow-up period of 915,387.5 person-years, 2403 incident cases of cerebral infarction developed between 2009 and 2013. After adjusting for multiple covariates, the hazard ratios (95% confidence interval) for incident cerebral infarction, comparing the second, third, and fourth quartile of serum gamma-glutamyltransferase levels with the first quartile, were 1.11 (0.98– 1.27), 1.39 (1.22– 1.58), and 1.49 (1.29– 1.71), respectively (P for trend < 0.001).Conclusion: Elevated serum gamma-glutamyltransferase levels were independently associated with the future development of cerebral infarction in Koreans.Keywords: gamma-glutamyltransferase, cerebral infarction, stroke
format	article
author	Lee SM Ha E Ryoo JH
author_facet	Lee SM Ha E Ryoo JH
author_sort	Lee SM
title	Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population
title_short	Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population
title_full	Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population
title_fullStr	Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population
title_full_unstemmed	Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population
title_sort	serum gamma-glutamyltransferase levels predict the development of cerebral infarction in the korean population
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a759569d3f2c4cfe97e8f050f8f72dd2
work_keys_str_mv	AT leesm serumgammaglutamyltransferaselevelspredictthedevelopmentofcerebralinfarctioninthekoreanpopulation AT hae serumgammaglutamyltransferaselevelspredictthedevelopmentofcerebralinfarctioninthekoreanpopulation AT ryoojh serumgammaglutamyltransferaselevelspredictthedevelopmentofcerebralinfarctioninthekoreanpopulation
_version_	1718387650415558656

Serum Gamma-Glutamyltransferase Levels Predict the Development of Cerebral Infarction in the Korean Population

Ejemplares similares