Gut dysbiosis and mortality in hemodialysis patients

Abstract Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RN...

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Autores principales:	Ting-Yun Lin, Ping-Hsun Wu, Yi-Ting Lin, Szu-Chun Hung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Microbial ecology QR100-130
Acceso en línea:	https://doaj.org/article/a7595e65c443421181e5bce176893339
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spelling	oai:doaj.org-article:a7595e65c443421181e5bce1768933392021-12-02T15:54:15ZGut dysbiosis and mortality in hemodialysis patients10.1038/s41522-021-00191-x2055-5008https://doaj.org/article/a7595e65c443421181e5bce1768933392021-03-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00191-xhttps://doaj.org/toc/2055-5008Abstract Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and Anaerostipes, two short-chain fatty acid-producing bacteria, was markedly reduced in nonsurvivors. Thus, a unique gut microbial composition is associated with an increased risk of mortality among hemodialysis patients and may be used to identify subjects with a poor prognosis.Ting-Yun LinPing-Hsun WuYi-Ting LinSzu-Chun HungNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbial ecology QR100-130
spellingShingle	Microbial ecology QR100-130 Ting-Yun Lin Ping-Hsun Wu Yi-Ting Lin Szu-Chun Hung Gut dysbiosis and mortality in hemodialysis patients
description	Abstract Little is known about the relationship between gut dysbiosis, inflammation, and adverse outcomes in patients with chronic kidney disease. We examined the association of microbial diversity with all-cause mortality in hemodialysis patients. The gut microbiota was assessed by 16S ribosomal RNA gene sequencing. During a median follow-up of 2.1 years, the adjusted risk of death among patients with higher diversity (above median) was 74% lower than that among patients with lower diversity (below median). We then compared the microbial composition between nonsurvivors and survivors in a matched case-control study. We observed significantly lower microbial diversity and higher proinflammatory cytokines among nonsurvivors than survivors. Specifically, the relative abundance of Succinivibrio and Anaerostipes, two short-chain fatty acid-producing bacteria, was markedly reduced in nonsurvivors. Thus, a unique gut microbial composition is associated with an increased risk of mortality among hemodialysis patients and may be used to identify subjects with a poor prognosis.
format	article
author	Ting-Yun Lin Ping-Hsun Wu Yi-Ting Lin Szu-Chun Hung
author_facet	Ting-Yun Lin Ping-Hsun Wu Yi-Ting Lin Szu-Chun Hung
author_sort	Ting-Yun Lin
title	Gut dysbiosis and mortality in hemodialysis patients
title_short	Gut dysbiosis and mortality in hemodialysis patients
title_full	Gut dysbiosis and mortality in hemodialysis patients
title_fullStr	Gut dysbiosis and mortality in hemodialysis patients
title_full_unstemmed	Gut dysbiosis and mortality in hemodialysis patients
title_sort	gut dysbiosis and mortality in hemodialysis patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a7595e65c443421181e5bce176893339
work_keys_str_mv	AT tingyunlin gutdysbiosisandmortalityinhemodialysispatients AT pinghsunwu gutdysbiosisandmortalityinhemodialysispatients AT yitinglin gutdysbiosisandmortalityinhemodialysispatients AT szuchunhung gutdysbiosisandmortalityinhemodialysispatients
_version_	1718385467680882688

Gut dysbiosis and mortality in hemodialysis patients

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