Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.

The distinction between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), two types of mature aggressive B-cell lymphomas that require distinct treatments, can be difficult because of forms showing features intermediate between DLBCL and BL (here called BL/DLBCL). They can be discrimi...

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Autores principales:	Julie Gonin, Frédérique Larousserie, Christian Bastard, Jean-Michel Picquenot, Jérôme Couturier, Isabelle Radford-Weiss, Céline Dietrich, Nicole Brousse, Marie-Cécile Vacher-Lavenu, Odile Devergne
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a759db1c2ae243f983e76502321cc628
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spelling	oai:doaj.org-article:a759db1c2ae243f983e76502321cc6282021-11-04T06:08:59ZEpstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.1932-620310.1371/journal.pone.0024617https://doaj.org/article/a759db1c2ae243f983e76502321cc6282011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21931777/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The distinction between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), two types of mature aggressive B-cell lymphomas that require distinct treatments, can be difficult because of forms showing features intermediate between DLBCL and BL (here called BL/DLBCL). They can be discriminated by the presence of c-myc translocations characteristic of BL. However, these are not exclusive of BL and when present in DLBCL are associated with lower survival. In this study, we show that Epstein-Barr virus-induced gene 3 (EBI3) is differentially expressed among BL and DLBCL. Analysis of gene expression data from 502 cases of aggressive mature B-cell lymphomas available on Gene Expression Omnibus and immunohistochemical analysis of 184 cases of BL, BL/DLBCL or DLBCL, showed that EBI3 was not expressed in EBV-positive or -negative BL cases, whereas it was expressed by over 30% of tumoral cells in nearly 80% of DLBCL cases, independently of their subtypes. In addition, we show that c-myc overexpression represses EBI3 expression, and that DLBCL or BL/DLBCL cases with c-myc translocations have lower expression of EBI3. Thus, EBI3 immunohistochemistry could be useful to discriminate BL from DLBCL, and to identify cases of BL/DLBCL or DLBCL with potential c-myc translocations.Julie GoninFrédérique LarousserieChristian BastardJean-Michel PicquenotJérôme CouturierIsabelle Radford-WeissCéline DietrichNicole BrousseMarie-Cécile Vacher-LavenuOdile DevergnePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24617 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julie Gonin Frédérique Larousserie Christian Bastard Jean-Michel Picquenot Jérôme Couturier Isabelle Radford-Weiss Céline Dietrich Nicole Brousse Marie-Cécile Vacher-Lavenu Odile Devergne Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
description	The distinction between Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), two types of mature aggressive B-cell lymphomas that require distinct treatments, can be difficult because of forms showing features intermediate between DLBCL and BL (here called BL/DLBCL). They can be discriminated by the presence of c-myc translocations characteristic of BL. However, these are not exclusive of BL and when present in DLBCL are associated with lower survival. In this study, we show that Epstein-Barr virus-induced gene 3 (EBI3) is differentially expressed among BL and DLBCL. Analysis of gene expression data from 502 cases of aggressive mature B-cell lymphomas available on Gene Expression Omnibus and immunohistochemical analysis of 184 cases of BL, BL/DLBCL or DLBCL, showed that EBI3 was not expressed in EBV-positive or -negative BL cases, whereas it was expressed by over 30% of tumoral cells in nearly 80% of DLBCL cases, independently of their subtypes. In addition, we show that c-myc overexpression represses EBI3 expression, and that DLBCL or BL/DLBCL cases with c-myc translocations have lower expression of EBI3. Thus, EBI3 immunohistochemistry could be useful to discriminate BL from DLBCL, and to identify cases of BL/DLBCL or DLBCL with potential c-myc translocations.
format	article
author	Julie Gonin Frédérique Larousserie Christian Bastard Jean-Michel Picquenot Jérôme Couturier Isabelle Radford-Weiss Céline Dietrich Nicole Brousse Marie-Cécile Vacher-Lavenu Odile Devergne
author_facet	Julie Gonin Frédérique Larousserie Christian Bastard Jean-Michel Picquenot Jérôme Couturier Isabelle Radford-Weiss Céline Dietrich Nicole Brousse Marie-Cécile Vacher-Lavenu Odile Devergne
author_sort	Julie Gonin
title	Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
title_short	Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
title_full	Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
title_fullStr	Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
title_full_unstemmed	Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.
title_sort	epstein-barr virus-induced gene 3 (ebi3): a novel diagnosis marker in burkitt lymphoma and diffuse large b-cell lymphoma.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a759db1c2ae243f983e76502321cc628
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Epstein-Barr virus-induced gene 3 (EBI3): a novel diagnosis marker in Burkitt lymphoma and diffuse large B-cell lymphoma.

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