Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group

Background Pouchitis is a non-specific inflammation of the ileal reservoir and the most frequent complication that patients experience in long periods. Diagnosis should be made based on the clinical, endoscopic, and histological aspects. Prediction of pouchitis is an important issue for the physici...

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Autor principal:	John F. Mayberry
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2013
Materias:	pregnancy psyllium haemorrhoids fissures trials Medicine R
Acceso en línea:	https://doaj.org/article/a75d26cf20da480baa06682f5fbb3bbc
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spelling	oai:doaj.org-article:a75d26cf20da480baa06682f5fbb3bbc2021-11-14T07:53:33ZOral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group2783-243010.17795/acr-14314https://doaj.org/article/a75d26cf20da480baa06682f5fbb3bbc2013-09-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_45445_ddb4450f34274513c1373aea6935a00e.pdfhttps://doaj.org/toc/2783-2430Background Pouchitis is a non-specific inflammation of the ileal reservoir and the most frequent complication that patients experience in long periods. Diagnosis should be made based on the clinical, endoscopic, and histological aspects. Prediction of pouchitis is an important issue for the physician. Objectives The study was aimed to identify the predictive factors of pouchitis as well as their importance. Patients and Methods In the present study, two classification techniques entitled decision trees method and logistic regression analysis were used to help the physician in prediction of pouchitis in ulcerative colitis (UC) patients. These patients are submitted to a specific surgery. The ability of these two methods in prediction is achieved by comparison of the accuracy of the correct predictions (the minimum error rate) and the interpretability and simplification of the results for clinical experts. Results The accuracy rate in prediction is 0.6 for logistic regression method and 0.45 for decision tree algorithm. In addition, the mean squared error is lower for logistic regression (0.41 versus 0.48). However, the area under the ROC is more for decision tree than logistic regression (0.52 and 0.45 respectively). Conclusions The results are not in favor of none of these two methods. However, the simplicity of decision tree for clinical experts and theoretical assumptions of logistic regression method make the choice clear. But more sample size may be needed to choose the best model with more confident.John F. MayberryShiraz University of Medical SciencesarticlepregnancypsylliumhaemorrhoidsfissurestrialsMedicineRENIranian Journal of Colorectal Research, Vol 1, Iss 2, Pp 0-0 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	pregnancy psyllium haemorrhoids fissures trials Medicine R
spellingShingle	pregnancy psyllium haemorrhoids fissures trials Medicine R John F. Mayberry Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group
description	Background Pouchitis is a non-specific inflammation of the ileal reservoir and the most frequent complication that patients experience in long periods. Diagnosis should be made based on the clinical, endoscopic, and histological aspects. Prediction of pouchitis is an important issue for the physician. Objectives The study was aimed to identify the predictive factors of pouchitis as well as their importance. Patients and Methods In the present study, two classification techniques entitled decision trees method and logistic regression analysis were used to help the physician in prediction of pouchitis in ulcerative colitis (UC) patients. These patients are submitted to a specific surgery. The ability of these two methods in prediction is achieved by comparison of the accuracy of the correct predictions (the minimum error rate) and the interpretability and simplification of the results for clinical experts. Results The accuracy rate in prediction is 0.6 for logistic regression method and 0.45 for decision tree algorithm. In addition, the mean squared error is lower for logistic regression (0.41 versus 0.48). However, the area under the ROC is more for decision tree than logistic regression (0.52 and 0.45 respectively). Conclusions The results are not in favor of none of these two methods. However, the simplicity of decision tree for clinical experts and theoretical assumptions of logistic regression method make the choice clear. But more sample size may be needed to choose the best model with more confident.
format	article
author	John F. Mayberry
author_facet	John F. Mayberry
author_sort	John F. Mayberry
title	Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group
title_short	Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group
title_full	Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group
title_fullStr	Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group
title_full_unstemmed	Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group
title_sort	oral psyllium herbal laxative, clinical trial in a difficult group
publisher	Shiraz University of Medical Sciences
publishDate	2013
url	https://doaj.org/article/a75d26cf20da480baa06682f5fbb3bbc
work_keys_str_mv	AT johnfmayberry oralpsylliumherballaxativeclinicaltrialinadifficultgroup
_version_	1718429856886161408

Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group

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