Effective combinatorial immunotherapy for penile squamous cell carcinoma

Penile squamous cell carcinoma (PSCC) is a cancer that is associated with significant mortality. Here, the authors develop a mouse model of PSCC by co-deletion of Smad4 and Apc in the androgen-responsive penile epithelium, and show synergistic efficacy of checkpoint therapy with cabozantinib or cele...

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Autores principales:	Tianhe Huang, Xi Cheng, Jad Chahoud, Ahmed Sarhan, Pheroze Tamboli, Priya Rao, Ming Guo, Ganiraju Manyam, Li Zhang, Yu Xiang, Leng Han, Xiaoying Shang, Pingna Deng, Yanting Luo, Xuemin Lu, Shan Feng, Magaly Martinez Ferrer, Y. Alan Wang, Ronald A. DePinho, Curtis A. Pettaway, Xin Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a75e587ee5244319a4b94f79be2430fb
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spelling	oai:doaj.org-article:a75e587ee5244319a4b94f79be2430fb2021-12-02T17:31:07ZEffective combinatorial immunotherapy for penile squamous cell carcinoma10.1038/s41467-020-15980-92041-1723https://doaj.org/article/a75e587ee5244319a4b94f79be2430fb2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15980-9https://doaj.org/toc/2041-1723Penile squamous cell carcinoma (PSCC) is a cancer that is associated with significant mortality. Here, the authors develop a mouse model of PSCC by co-deletion of Smad4 and Apc in the androgen-responsive penile epithelium, and show synergistic efficacy of checkpoint therapy with cabozantinib or celecoxib in their model.Tianhe HuangXi ChengJad ChahoudAhmed SarhanPheroze TamboliPriya RaoMing GuoGaniraju ManyamLi ZhangYu XiangLeng HanXiaoying ShangPingna DengYanting LuoXuemin LuShan FengMagaly Martinez FerrerY. Alan WangRonald A. DePinhoCurtis A. PettawayXin LuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tianhe Huang Xi Cheng Jad Chahoud Ahmed Sarhan Pheroze Tamboli Priya Rao Ming Guo Ganiraju Manyam Li Zhang Yu Xiang Leng Han Xiaoying Shang Pingna Deng Yanting Luo Xuemin Lu Shan Feng Magaly Martinez Ferrer Y. Alan Wang Ronald A. DePinho Curtis A. Pettaway Xin Lu Effective combinatorial immunotherapy for penile squamous cell carcinoma
description	Penile squamous cell carcinoma (PSCC) is a cancer that is associated with significant mortality. Here, the authors develop a mouse model of PSCC by co-deletion of Smad4 and Apc in the androgen-responsive penile epithelium, and show synergistic efficacy of checkpoint therapy with cabozantinib or celecoxib in their model.
format	article
author	Tianhe Huang Xi Cheng Jad Chahoud Ahmed Sarhan Pheroze Tamboli Priya Rao Ming Guo Ganiraju Manyam Li Zhang Yu Xiang Leng Han Xiaoying Shang Pingna Deng Yanting Luo Xuemin Lu Shan Feng Magaly Martinez Ferrer Y. Alan Wang Ronald A. DePinho Curtis A. Pettaway Xin Lu
author_facet	Tianhe Huang Xi Cheng Jad Chahoud Ahmed Sarhan Pheroze Tamboli Priya Rao Ming Guo Ganiraju Manyam Li Zhang Yu Xiang Leng Han Xiaoying Shang Pingna Deng Yanting Luo Xuemin Lu Shan Feng Magaly Martinez Ferrer Y. Alan Wang Ronald A. DePinho Curtis A. Pettaway Xin Lu
author_sort	Tianhe Huang
title	Effective combinatorial immunotherapy for penile squamous cell carcinoma
title_short	Effective combinatorial immunotherapy for penile squamous cell carcinoma
title_full	Effective combinatorial immunotherapy for penile squamous cell carcinoma
title_fullStr	Effective combinatorial immunotherapy for penile squamous cell carcinoma
title_full_unstemmed	Effective combinatorial immunotherapy for penile squamous cell carcinoma
title_sort	effective combinatorial immunotherapy for penile squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a75e587ee5244319a4b94f79be2430fb
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_version_	1718380691100532736

Effective combinatorial immunotherapy for penile squamous cell carcinoma

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