Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer

Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-specific role for epithelial Stat3 signaling in K-ras-m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mauricio S. Caetano, Maya Hassane, Hieu T. Van, Emmanuel Bugarin, Amber M. Cumpian, Christina L. McDowell, Carolina Gonzalez Cavazos, Huiyuan Zhang, Shanshan Deng, Lixia Diao, Jing Wang, Scott E. Evans, Carmen Behrens, Ignacio I. Wistuba, Susan A. W. Fuqua, Huang Lin, Laura P. Stabile, Stephanie S. Watowich, Humam Kadara, Seyed Javad Moghaddam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a75e60d748374ccbaa270592719a5d9b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a75e60d748374ccbaa270592719a5d9b
record_format	dspace
spelling	oai:doaj.org-article:a75e60d748374ccbaa270592719a5d9b2021-12-02T17:31:59ZSex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer10.1038/s41467-018-07042-y2041-1723https://doaj.org/article/a75e60d748374ccbaa270592719a5d9b2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07042-yhttps://doaj.org/toc/2041-1723Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-specific role for epithelial Stat3 signaling in K-ras-mutant LUAD.Mauricio S. CaetanoMaya HassaneHieu T. VanEmmanuel BugarinAmber M. CumpianChristina L. McDowellCarolina Gonzalez CavazosHuiyuan ZhangShanshan DengLixia DiaoJing WangScott E. EvansCarmen BehrensIgnacio I. WistubaSusan A. W. FuquaHuang LinLaura P. StabileStephanie S. WatowichHumam KadaraSeyed Javad MoghaddamNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mauricio S. Caetano Maya Hassane Hieu T. Van Emmanuel Bugarin Amber M. Cumpian Christina L. McDowell Carolina Gonzalez Cavazos Huiyuan Zhang Shanshan Deng Lixia Diao Jing Wang Scott E. Evans Carmen Behrens Ignacio I. Wistuba Susan A. W. Fuqua Huang Lin Laura P. Stabile Stephanie S. Watowich Humam Kadara Seyed Javad Moghaddam Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
description	Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-specific role for epithelial Stat3 signaling in K-ras-mutant LUAD.
format	article
author	Mauricio S. Caetano Maya Hassane Hieu T. Van Emmanuel Bugarin Amber M. Cumpian Christina L. McDowell Carolina Gonzalez Cavazos Huiyuan Zhang Shanshan Deng Lixia Diao Jing Wang Scott E. Evans Carmen Behrens Ignacio I. Wistuba Susan A. W. Fuqua Huang Lin Laura P. Stabile Stephanie S. Watowich Humam Kadara Seyed Javad Moghaddam
author_facet	Mauricio S. Caetano Maya Hassane Hieu T. Van Emmanuel Bugarin Amber M. Cumpian Christina L. McDowell Carolina Gonzalez Cavazos Huiyuan Zhang Shanshan Deng Lixia Diao Jing Wang Scott E. Evans Carmen Behrens Ignacio I. Wistuba Susan A. W. Fuqua Huang Lin Laura P. Stabile Stephanie S. Watowich Humam Kadara Seyed Javad Moghaddam
author_sort	Mauricio S. Caetano
title	Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
title_short	Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
title_full	Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
title_fullStr	Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
title_full_unstemmed	Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer
title_sort	sex specific function of epithelial stat3 signaling in pathogenesis of k-ras mutant lung cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a75e60d748374ccbaa270592719a5d9b
work_keys_str_mv	AT mauricioscaetano sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT mayahassane sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT hieutvan sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT emmanuelbugarin sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT ambermcumpian sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT christinalmcdowell sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT carolinagonzalezcavazos sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT huiyuanzhang sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT shanshandeng sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT lixiadiao sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT jingwang sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT scotteevans sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT carmenbehrens sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT ignacioiwistuba sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT susanawfuqua sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT huanglin sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT laurapstabile sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT stephanieswatowich sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT humamkadara sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer AT seyedjavadmoghaddam sexspecificfunctionofepithelialstat3signalinginpathogenesisofkrasmutantlungcancer
_version_	1718380446933319680

Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer

Ejemplares similares