Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid

Isoniazid (INH) is an anti-tuberculosis drug; however the underlying cause of its various side effects are not understood. Here the authors identified lysine isonicotinylation as a histone modification on chromatin that is metabolically regulated by INH and its metabolites.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuhan Jiang, Yixiao Li, Cheng Liu, Lei Zhang, Danyu Lv, Yejing Weng, Zhongyi Cheng, Xiangmei Chen, Jun Zhan, Hongquan Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a75ea7e77a4d4edc993060b25acbbf6e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a75ea7e77a4d4edc993060b25acbbf6e
record_format	dspace
spelling	oai:doaj.org-article:a75ea7e77a4d4edc993060b25acbbf6e2021-12-02T18:48:11ZIsonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid10.1038/s41467-021-25867-y2041-1723https://doaj.org/article/a75ea7e77a4d4edc993060b25acbbf6e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25867-yhttps://doaj.org/toc/2041-1723Isoniazid (INH) is an anti-tuberculosis drug; however the underlying cause of its various side effects are not understood. Here the authors identified lysine isonicotinylation as a histone modification on chromatin that is metabolically regulated by INH and its metabolites.Yuhan JiangYixiao LiCheng LiuLei ZhangDanyu LvYejing WengZhongyi ChengXiangmei ChenJun ZhanHongquan ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuhan Jiang Yixiao Li Cheng Liu Lei Zhang Danyu Lv Yejing Weng Zhongyi Cheng Xiangmei Chen Jun Zhan Hongquan Zhang Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
description	Isoniazid (INH) is an anti-tuberculosis drug; however the underlying cause of its various side effects are not understood. Here the authors identified lysine isonicotinylation as a histone modification on chromatin that is metabolically regulated by INH and its metabolites.
format	article
author	Yuhan Jiang Yixiao Li Cheng Liu Lei Zhang Danyu Lv Yejing Weng Zhongyi Cheng Xiangmei Chen Jun Zhan Hongquan Zhang
author_facet	Yuhan Jiang Yixiao Li Cheng Liu Lei Zhang Danyu Lv Yejing Weng Zhongyi Cheng Xiangmei Chen Jun Zhan Hongquan Zhang
author_sort	Yuhan Jiang
title	Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
title_short	Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
title_full	Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
title_fullStr	Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
title_full_unstemmed	Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
title_sort	isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a75ea7e77a4d4edc993060b25acbbf6e
work_keys_str_mv	AT yuhanjiang isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT yixiaoli isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT chengliu isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT leizhang isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT danyulv isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT yejingweng isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT zhongyicheng isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT xiangmeichen isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT junzhan isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid AT hongquanzhang isonicotinylationisahistonemarkinducedbytheantituberculosisfirstlinedrugisoniazid
_version_	1718377642165534720

Isonicotinylation is a histone mark induced by the anti-tuberculosis first-line drug isoniazid

Ejemplares similares