Extracellular mRNA transported to the nucleus exerts translation-independent function

Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.

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Autores principales:	Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi, Toshifumi Takao, Noriki Iwai, Takashi Mino, Osamu Takeuchi, Yoshiro Maru, Sachie Hiratsuka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a75fe0cb0a7242eda55465abbb5ce4d8
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spelling	oai:doaj.org-article:a75fe0cb0a7242eda55465abbb5ce4d82021-12-02T16:04:25ZExtracellular mRNA transported to the nucleus exerts translation-independent function10.1038/s41467-021-23969-12041-1723https://doaj.org/article/a75fe0cb0a7242eda55465abbb5ce4d82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23969-1https://doaj.org/toc/2041-1723Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.Takeshi TomitaMasayoshi KatoTaishi MishimaYuta MatsunagaHideki SanjoKen-ichi ItoKentaro MinagawaToshimitsu MatsuiHiroyuki OikawaSatoshi TakahashiToshifumi TakaoNoriki IwaiTakashi MinoOsamu TakeuchiYoshiro MaruSachie HiratsukaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takeshi Tomita Masayoshi Kato Taishi Mishima Yuta Matsunaga Hideki Sanjo Ken-ichi Ito Kentaro Minagawa Toshimitsu Matsui Hiroyuki Oikawa Satoshi Takahashi Toshifumi Takao Noriki Iwai Takashi Mino Osamu Takeuchi Yoshiro Maru Sachie Hiratsuka Extracellular mRNA transported to the nucleus exerts translation-independent function
description	Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.
format	article
author	Takeshi Tomita Masayoshi Kato Taishi Mishima Yuta Matsunaga Hideki Sanjo Ken-ichi Ito Kentaro Minagawa Toshimitsu Matsui Hiroyuki Oikawa Satoshi Takahashi Toshifumi Takao Noriki Iwai Takashi Mino Osamu Takeuchi Yoshiro Maru Sachie Hiratsuka
author_facet	Takeshi Tomita Masayoshi Kato Taishi Mishima Yuta Matsunaga Hideki Sanjo Ken-ichi Ito Kentaro Minagawa Toshimitsu Matsui Hiroyuki Oikawa Satoshi Takahashi Toshifumi Takao Noriki Iwai Takashi Mino Osamu Takeuchi Yoshiro Maru Sachie Hiratsuka
author_sort	Takeshi Tomita
title	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_short	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_full	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_fullStr	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_full_unstemmed	Extracellular mRNA transported to the nucleus exerts translation-independent function
title_sort	extracellular mrna transported to the nucleus exerts translation-independent function
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a75fe0cb0a7242eda55465abbb5ce4d8
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Extracellular mRNA transported to the nucleus exerts translation-independent function

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