Extracellular mRNA transported to the nucleus exerts translation-independent function

Extracellular mRNA transported to the nucleus exerts translation-independent function

Nonvesicular extracellular RNA (nex-RNA) that are not packed in extracellular vesicles is detected outside the cell, but it is poorly understood. Here the authors report that nex-RNA is captured by a zinc finger protein and transported to the nucleus to enhance antimetastatic characters of the cell.

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Bibliographic Details
Main Authors: Takeshi Tomita, Masayoshi Kato, Taishi Mishima, Yuta Matsunaga, Hideki Sanjo, Ken-ichi Ito, Kentaro Minagawa, Toshimitsu Matsui, Hiroyuki Oikawa, Satoshi Takahashi, Toshifumi Takao, Noriki Iwai, Takashi Mino, Osamu Takeuchi, Yoshiro Maru, Sachie Hiratsuka
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/a75fe0cb0a7242eda55465abbb5ce4d8
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Internet

https://doaj.org/article/a75fe0cb0a7242eda55465abbb5ce4d8

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