Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population
Foteini Tsapardoni,1 Olga E Makri,1 Vasileios Lazaris,2 Vassiliki Labropoulou,2 Spyridon Lygeros,3 Stylianos Mastronikolis,1 Alexandra Kouraklis,2 Argiris Symeonidis,2 Constantinos D Georgakopoulos1 1Department of Ophthalmology, University Hospital of Patras, Patras, Greece; 2Hematology Division, De...
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Dove Medical Press
2020
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oai:doaj.org-article:a761d00c38734e0db97133b822549eb32021-12-02T13:35:45ZChoroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population1177-5483https://doaj.org/article/a761d00c38734e0db97133b822549eb32020-12-01T00:00:00Zhttps://www.dovepress.com/choroidal-thickness-evaluation-in-a-transfusion-dependent-beta-thalass-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Foteini Tsapardoni,1 Olga E Makri,1 Vasileios Lazaris,2 Vassiliki Labropoulou,2 Spyridon Lygeros,3 Stylianos Mastronikolis,1 Alexandra Kouraklis,2 Argiris Symeonidis,2 Constantinos D Georgakopoulos1 1Department of Ophthalmology, University Hospital of Patras, Patras, Greece; 2Hematology Division, Department of Internal Medicine, University Hospital of Patras, Patras, Greece; 3Medical School, University of Patras, Patras, GreeceCorrespondence: Constantinos D GeorgakopoulosOphthalmology Department, University Hospital of Patras, Patras, GR 26504, GreeceTel +30 2610999262Fax +30 2610 993994Email cgeorg@upatras.grPurpose: To evaluate choroidal thickness in a group of beta-thalassemia patients as assessed by enhanced depth imaging optical coherence tomography.Patients and Methods: This single-center, observational study involved transfusion-dependent beta-thalassemia (TD-β-thal) patients and healthy controls. One eye of each participant was included in the study. Submacular and peripapillary choroidal thickness, as well as central macular thickness and retinal nerve fiber layer thickness, were evaluated.Results: Thirty-eight TD-β-thal patients (mean age 42 ± 10.7 years) and 22 healthy controls (mean age 40.3 ± 10.2 years) were included in the study. Subfoveal choroidal thickness was 297.4 ± 74.5 μm in the patient group and 358.4 ± 71.4 μm in the control group (p=0.003). Overall, in the submacular area, the choroid was found to be significantly thinner in the beta-thalassemia population compared to controls in all evaluated points, except for the spot located 1500 μm nasally to the fovea (p=0.093). In the peripapillary area, choroidal thickness was also significantly lower in the thalassemic population compared to the controls (nasal p=0.033, temporal p=0.01, superior p=0.01), except for the inferior quadrant (p= 0.191). We did not observe statistically significant differences in the retinal nerve fiber layer thickness and the central macular thickness between the two groups (p=0.658 and p=0.276, respectively). No correlations with hemoglobin, serum ferritin or iron levels emerged. Patients with the intermediate subtype appeared to have significantly thinner choroids than the ones with thalassemia major.Conclusion: Our findings suggest that choroidal thickness in the submacular and peripapillary area is significantly reduced in thalassemic patients, compared to healthy individuals. Choroidal thinning in beta-thalassemia possibly reflects the effect of chronic anemia and underlying hemodynamic changes on choroidal tissue.Keywords: central macular thickness, retinal nerve fiber layer thickness, iron chelation treatment, erythrocyte transfusionTsapardoni FMakri OELazaris VLabropoulou VLygeros SMastronikolis SKouraklis ASymeonidis AGeorgakopoulos CDDove Medical Pressarticlecentral macular thicknessretinal nerve fiber layer thicknessiron chelation treatmenterythrocyte transfusionOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 4511-4518 (2020) |
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central macular thickness retinal nerve fiber layer thickness iron chelation treatment erythrocyte transfusion Ophthalmology RE1-994 |
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central macular thickness retinal nerve fiber layer thickness iron chelation treatment erythrocyte transfusion Ophthalmology RE1-994 Tsapardoni F Makri OE Lazaris V Labropoulou V Lygeros S Mastronikolis S Kouraklis A Symeonidis A Georgakopoulos CD Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population |
| description |
Foteini Tsapardoni,1 Olga E Makri,1 Vasileios Lazaris,2 Vassiliki Labropoulou,2 Spyridon Lygeros,3 Stylianos Mastronikolis,1 Alexandra Kouraklis,2 Argiris Symeonidis,2 Constantinos D Georgakopoulos1 1Department of Ophthalmology, University Hospital of Patras, Patras, Greece; 2Hematology Division, Department of Internal Medicine, University Hospital of Patras, Patras, Greece; 3Medical School, University of Patras, Patras, GreeceCorrespondence: Constantinos D GeorgakopoulosOphthalmology Department, University Hospital of Patras, Patras, GR 26504, GreeceTel +30 2610999262Fax +30 2610 993994Email cgeorg@upatras.grPurpose: To evaluate choroidal thickness in a group of beta-thalassemia patients as assessed by enhanced depth imaging optical coherence tomography.Patients and Methods: This single-center, observational study involved transfusion-dependent beta-thalassemia (TD-β-thal) patients and healthy controls. One eye of each participant was included in the study. Submacular and peripapillary choroidal thickness, as well as central macular thickness and retinal nerve fiber layer thickness, were evaluated.Results: Thirty-eight TD-β-thal patients (mean age 42 ± 10.7 years) and 22 healthy controls (mean age 40.3 ± 10.2 years) were included in the study. Subfoveal choroidal thickness was 297.4 ± 74.5 μm in the patient group and 358.4 ± 71.4 μm in the control group (p=0.003). Overall, in the submacular area, the choroid was found to be significantly thinner in the beta-thalassemia population compared to controls in all evaluated points, except for the spot located 1500 μm nasally to the fovea (p=0.093). In the peripapillary area, choroidal thickness was also significantly lower in the thalassemic population compared to the controls (nasal p=0.033, temporal p=0.01, superior p=0.01), except for the inferior quadrant (p= 0.191). We did not observe statistically significant differences in the retinal nerve fiber layer thickness and the central macular thickness between the two groups (p=0.658 and p=0.276, respectively). No correlations with hemoglobin, serum ferritin or iron levels emerged. Patients with the intermediate subtype appeared to have significantly thinner choroids than the ones with thalassemia major.Conclusion: Our findings suggest that choroidal thickness in the submacular and peripapillary area is significantly reduced in thalassemic patients, compared to healthy individuals. Choroidal thinning in beta-thalassemia possibly reflects the effect of chronic anemia and underlying hemodynamic changes on choroidal tissue.Keywords: central macular thickness, retinal nerve fiber layer thickness, iron chelation treatment, erythrocyte transfusion |
| format |
article |
| author |
Tsapardoni F Makri OE Lazaris V Labropoulou V Lygeros S Mastronikolis S Kouraklis A Symeonidis A Georgakopoulos CD |
| author_facet |
Tsapardoni F Makri OE Lazaris V Labropoulou V Lygeros S Mastronikolis S Kouraklis A Symeonidis A Georgakopoulos CD |
| author_sort |
Tsapardoni F |
| title |
Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population |
| title_short |
Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population |
| title_full |
Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population |
| title_fullStr |
Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population |
| title_full_unstemmed |
Choroidal Thickness Evaluation in a Transfusion-Dependent Beta-Thalassemia Greek Population |
| title_sort |
choroidal thickness evaluation in a transfusion-dependent beta-thalassemia greek population |
| publisher |
Dove Medical Press |
| publishDate |
2020 |
| url |
https://doaj.org/article/a761d00c38734e0db97133b822549eb3 |
| work_keys_str_mv |
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