The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement

Alyssa Ricker, Peishan Liu-Snyder, Thomas J WebsterDivision of Engineering, Brown University, Providence, RI, USAAbstract: A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement...

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Autores principales:	Alyssa Ricker, Peishan Liu-Snyder, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a7695f2547d84f0ca9bb21d3b30ca81b
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spelling	oai:doaj.org-article:a7695f2547d84f0ca9bb21d3b30ca81b2021-12-02T02:10:28ZThe influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement1176-91141178-2013https://doaj.org/article/a7695f2547d84f0ca9bb21d3b30ca81b2008-03-01T00:00:00Zhttp://www.dovepress.com/the-influence-of-nano-mgo-and-baso4-particle-size-additives-on-propert-a746https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Alyssa Ricker, Peishan Liu-Snyder, Thomas J WebsterDivision of Engineering, Brown University, Providence, RI, USAAbstract: A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages of using PMMA in bone fixation applications which has limited its wide spread use. Specifically, the PMMA polymerization reaction is highly exothermic in situ, thus, damaging surrounding bone tissue while curing. In addition, PMMA by itself is not visible using typical medical imaging techniques (such as X-rays required to assess new bone formation surrounding the implant). Lastly, although PMMA does support new bone growth, studies have highlighted decreased osteoblast (bone forming cell) functions on PMMA compared to other common orthopedic coating materials, such as calcium phosphates and hydroxyapatite. For these reasons, the goal of this study was to begin to investigate novel additives to PMMA which can enhance its cytocompatibility properties with osteoblasts, decrease its exothermic reaction when curing, and increase its radiopacity. Results of this study demonstrated that compared to conventional (or micron) equivalents, PMMA with nanoparticles of MgO and BaSO4 reduced harmful exothermic reactions of PMMA during solidification and increased radiopacity, respectively. Moreover, osteoblast adhesion increased on PMMA with nanoparticles of MgO and BaSO4 compared with PMMA alone. This study, thus, suggests that nanoparticles of MgO and BaSO4 should be further studied for improving properties of PMMA for orthopedic applications.Keywords: bone cement, PMMA, Poly(methyl methacrylate), osteoblast, nanoparticles Alyssa RickerPeishan Liu-SnyderThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 1, Pp 125-132 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Alyssa Ricker Peishan Liu-Snyder Thomas J Webster The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
description	Alyssa Ricker, Peishan Liu-Snyder, Thomas J WebsterDivision of Engineering, Brown University, Providence, RI, USAAbstract: A common technique to aid in implant fixation into surrounding bone is to inject bone cement into the space between the implant and surrounding bone. The most common bone cement material used clinically today is poly(methyl methacrylate), or PMMA. Although promising, there are numerous disadvantages of using PMMA in bone fixation applications which has limited its wide spread use. Specifically, the PMMA polymerization reaction is highly exothermic in situ, thus, damaging surrounding bone tissue while curing. In addition, PMMA by itself is not visible using typical medical imaging techniques (such as X-rays required to assess new bone formation surrounding the implant). Lastly, although PMMA does support new bone growth, studies have highlighted decreased osteoblast (bone forming cell) functions on PMMA compared to other common orthopedic coating materials, such as calcium phosphates and hydroxyapatite. For these reasons, the goal of this study was to begin to investigate novel additives to PMMA which can enhance its cytocompatibility properties with osteoblasts, decrease its exothermic reaction when curing, and increase its radiopacity. Results of this study demonstrated that compared to conventional (or micron) equivalents, PMMA with nanoparticles of MgO and BaSO4 reduced harmful exothermic reactions of PMMA during solidification and increased radiopacity, respectively. Moreover, osteoblast adhesion increased on PMMA with nanoparticles of MgO and BaSO4 compared with PMMA alone. This study, thus, suggests that nanoparticles of MgO and BaSO4 should be further studied for improving properties of PMMA for orthopedic applications.Keywords: bone cement, PMMA, Poly(methyl methacrylate), osteoblast, nanoparticles
format	article
author	Alyssa Ricker Peishan Liu-Snyder Thomas J Webster
author_facet	Alyssa Ricker Peishan Liu-Snyder Thomas J Webster
author_sort	Alyssa Ricker
title	The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
title_short	The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
title_full	The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
title_fullStr	The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
title_full_unstemmed	The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement
title_sort	influence of nano mgo and baso4 particle size additives on properties of pmma bone cement
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/a7695f2547d84f0ca9bb21d3b30ca81b
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The influence of nano MgO and BaSO4 particle size additives on properties of PMMA bone cement

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