Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials

Aortic stenosis is a progressive disease that develops over decades, and once symptomatic and untreated, is associated with poor survival. Transcatheter aortic valve replacement has evolved significantly in the past decade and has expanded its indication from surgically inoperable and high-risk pati...

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Autores principales:	Ernest Spitzer, Rebecca T Hahn, Philippe Pibarot, Ton de Vries, Jeroen J Bax, Martin B Leon, Nicolas M Van Mieghem
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/a770e270785e4086ae02f7c3e2b058e9
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spelling	oai:doaj.org-article:a770e270785e4086ae02f7c3e2b058e92021-12-04T16:01:36ZAortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials10.15420/cfr.2018.41.22057-75592057-7540https://doaj.org/article/a770e270785e4086ae02f7c3e2b058e92019-05-01T00:00:00Zhttps://www.cfrjournal.com/articles/Aortic-Stenosis-Heart-Failure-Clinical-Trialshttps://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559Aortic stenosis is a progressive disease that develops over decades, and once symptomatic and untreated, is associated with poor survival. Transcatheter aortic valve replacement has evolved significantly in the past decade and has expanded its indication from surgically inoperable and high-risk patients to patients with intermediate risk. Assessment of heart failure-related outcomes include the use of functional assessments, disease-specific quality of life surveys and standardised ascertainment of events, such as hospitalisations. Multiple statistical approaches are currently being tested to account for recurrent events such as hospitalisations for heart failure or to combine binary and continuous outcomes, both intended to assess the holistic burden of the disease, as opposed to the traditional analysis of time to first event.Ernest SpitzerRebecca T HahnPhilippe PibarotTon de VriesJeroen J BaxMartin B LeonNicolas M Van MieghemRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 5, Iss 2, Pp 99-105 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Ernest Spitzer Rebecca T Hahn Philippe Pibarot Ton de Vries Jeroen J Bax Martin B Leon Nicolas M Van Mieghem Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials
description	Aortic stenosis is a progressive disease that develops over decades, and once symptomatic and untreated, is associated with poor survival. Transcatheter aortic valve replacement has evolved significantly in the past decade and has expanded its indication from surgically inoperable and high-risk patients to patients with intermediate risk. Assessment of heart failure-related outcomes include the use of functional assessments, disease-specific quality of life surveys and standardised ascertainment of events, such as hospitalisations. Multiple statistical approaches are currently being tested to account for recurrent events such as hospitalisations for heart failure or to combine binary and continuous outcomes, both intended to assess the holistic burden of the disease, as opposed to the traditional analysis of time to first event.
format	article
author	Ernest Spitzer Rebecca T Hahn Philippe Pibarot Ton de Vries Jeroen J Bax Martin B Leon Nicolas M Van Mieghem
author_facet	Ernest Spitzer Rebecca T Hahn Philippe Pibarot Ton de Vries Jeroen J Bax Martin B Leon Nicolas M Van Mieghem
author_sort	Ernest Spitzer
title	Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials
title_short	Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials
title_full	Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials
title_fullStr	Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials
title_full_unstemmed	Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials
title_sort	aortic stenosis and heart failure: disease ascertainment and statistical considerations for clinical trials
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/a770e270785e4086ae02f7c3e2b058e9
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Aortic Stenosis and Heart Failure: Disease Ascertainment and Statistical Considerations for Clinical Trials

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