Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

High-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and current evidences link E7 to HPV-associated carcinogenesis. Here the authors propose a model in which the infection of epithelial cells with high risk HPV results in a burst of reactive oxygen species,...

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Autores principales:	Yuan Liu, Ji-Zheng Guo, Ying Liu, Kui Wang, Wencheng Ding, Hui Wang, Xiang Liu, Shengtao Zhou, Xiao-Chen Lu, Hong-Bin Yang, Chenyue Xu, Wei Gao, Li Zhou, Yi-Ping Wang, Weiguo Hu, Yuquan Wei, Canhua Huang, Qun-Ying Lei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a77265bfdf7b44d1aae182171c371652
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spelling	oai:doaj.org-article:a77265bfdf7b44d1aae182171c3716522021-12-02T17:31:26ZNuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth10.1038/s41467-018-06841-72041-1723https://doaj.org/article/a77265bfdf7b44d1aae182171c3716522018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06841-7https://doaj.org/toc/2041-1723High-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and current evidences link E7 to HPV-associated carcinogenesis. Here the authors propose a model in which the infection of epithelial cells with high risk HPV results in a burst of reactive oxygen species, translocation of LDHA to the nucleus and activation of a gene profile that supports the growth of cervical cancer.Yuan LiuJi-Zheng GuoYing LiuKui WangWencheng DingHui WangXiang LiuShengtao ZhouXiao-Chen LuHong-Bin YangChenyue XuWei GaoLi ZhouYi-Ping WangWeiguo HuYuquan WeiCanhua HuangQun-Ying LeiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Liu Ji-Zheng Guo Ying Liu Kui Wang Wencheng Ding Hui Wang Xiang Liu Shengtao Zhou Xiao-Chen Lu Hong-Bin Yang Chenyue Xu Wei Gao Li Zhou Yi-Ping Wang Weiguo Hu Yuquan Wei Canhua Huang Qun-Ying Lei Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
description	High-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and current evidences link E7 to HPV-associated carcinogenesis. Here the authors propose a model in which the infection of epithelial cells with high risk HPV results in a burst of reactive oxygen species, translocation of LDHA to the nucleus and activation of a gene profile that supports the growth of cervical cancer.
format	article
author	Yuan Liu Ji-Zheng Guo Ying Liu Kui Wang Wencheng Ding Hui Wang Xiang Liu Shengtao Zhou Xiao-Chen Lu Hong-Bin Yang Chenyue Xu Wei Gao Li Zhou Yi-Ping Wang Weiguo Hu Yuquan Wei Canhua Huang Qun-Ying Lei
author_facet	Yuan Liu Ji-Zheng Guo Ying Liu Kui Wang Wencheng Ding Hui Wang Xiang Liu Shengtao Zhou Xiao-Chen Lu Hong-Bin Yang Chenyue Xu Wei Gao Li Zhou Yi-Ping Wang Weiguo Hu Yuquan Wei Canhua Huang Qun-Ying Lei
author_sort	Yuan Liu
title	Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
title_short	Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
title_full	Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
title_fullStr	Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
title_full_unstemmed	Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth
title_sort	nuclear lactate dehydrogenase a senses ros to produce α-hydroxybutyrate for hpv-induced cervical tumor growth
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a77265bfdf7b44d1aae182171c371652
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Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

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