Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression

miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung cancer initiation and metastasis and could serve as pr...

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Autores principales:	Wen Cai Zhang, Tan Min Chin, Henry Yang, Min En Nga, Declan Patrick Lunny, Edwin Kok Hao Lim, Li Li Sun, Yin Huei Pang, Yi Ning Leow, Shanneen Rossellini Y Malusay, Priscilla Xin Hui Lim, Jeravan Zili Lee, Benedict Jian Wei Tan, Ng Shyh-Chang, Elaine Hsuen Lim, Wan Teck Lim, Daniel Shao Weng Tan, Eng Huat Tan, Bee Choo Tai, Ross Andrew Soo, Wai Leong Tam, Bing Lim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a77285cd13d847d6a9987229f6e39d6d
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spelling	oai:doaj.org-article:a77285cd13d847d6a9987229f6e39d6d2021-12-02T17:32:50ZTumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression10.1038/ncomms117022041-1723https://doaj.org/article/a77285cd13d847d6a9987229f6e39d6d2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11702https://doaj.org/toc/2041-1723miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung cancer initiation and metastasis and could serve as prognostic markers.Wen Cai ZhangTan Min ChinHenry YangMin En NgaDeclan Patrick LunnyEdwin Kok Hao LimLi Li SunYin Huei PangYi Ning LeowShanneen Rossellini Y MalusayPriscilla Xin Hui LimJeravan Zili LeeBenedict Jian Wei TanNg Shyh-ChangElaine Hsuen LimWan Teck LimDaniel Shao Weng TanEng Huat TanBee Choo TaiRoss Andrew SooWai Leong TamBing LimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wen Cai Zhang Tan Min Chin Henry Yang Min En Nga Declan Patrick Lunny Edwin Kok Hao Lim Li Li Sun Yin Huei Pang Yi Ning Leow Shanneen Rossellini Y Malusay Priscilla Xin Hui Lim Jeravan Zili Lee Benedict Jian Wei Tan Ng Shyh-Chang Elaine Hsuen Lim Wan Teck Lim Daniel Shao Weng Tan Eng Huat Tan Bee Choo Tai Ross Andrew Soo Wai Leong Tam Bing Lim Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
description	miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung cancer initiation and metastasis and could serve as prognostic markers.
format	article
author	Wen Cai Zhang Tan Min Chin Henry Yang Min En Nga Declan Patrick Lunny Edwin Kok Hao Lim Li Li Sun Yin Huei Pang Yi Ning Leow Shanneen Rossellini Y Malusay Priscilla Xin Hui Lim Jeravan Zili Lee Benedict Jian Wei Tan Ng Shyh-Chang Elaine Hsuen Lim Wan Teck Lim Daniel Shao Weng Tan Eng Huat Tan Bee Choo Tai Ross Andrew Soo Wai Leong Tam Bing Lim
author_facet	Wen Cai Zhang Tan Min Chin Henry Yang Min En Nga Declan Patrick Lunny Edwin Kok Hao Lim Li Li Sun Yin Huei Pang Yi Ning Leow Shanneen Rossellini Y Malusay Priscilla Xin Hui Lim Jeravan Zili Lee Benedict Jian Wei Tan Ng Shyh-Chang Elaine Hsuen Lim Wan Teck Lim Daniel Shao Weng Tan Eng Huat Tan Bee Choo Tai Ross Andrew Soo Wai Leong Tam Bing Lim
author_sort	Wen Cai Zhang
title	Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
title_short	Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
title_full	Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
title_fullStr	Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
title_full_unstemmed	Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
title_sort	tumour-initiating cell-specific mir-1246 and mir-1290 expression converge to promote non-small cell lung cancer progression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a77285cd13d847d6a9987229f6e39d6d
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Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression

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