The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice
Abstract Adverse experience in early life can affect the formation of neuronal circuits during postnatal development and exert long-lasting influences on neural functions that can lead to the development of a variety of psychiatric disorders including depression, anxiety disorders, and post-traumati...
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Nature Portfolio
2021
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oai:doaj.org-article:a77cd609752841f2b86267da7da705802021-12-02T14:01:24ZThe effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice10.1038/s41598-020-80206-32045-2322https://doaj.org/article/a77cd609752841f2b86267da7da705802021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80206-3https://doaj.org/toc/2045-2322Abstract Adverse experience in early life can affect the formation of neuronal circuits during postnatal development and exert long-lasting influences on neural functions that can lead to the development of a variety of psychiatric disorders including depression, anxiety disorders, and post-traumatic stress disorder. Many studies have demonstrated that daily repeated maternal separation, an animal model of early-life stress, can induce impairments in emotional behaviours and cognitive function during adolescence and adulthood. However, the behavioural phenotypes of maternally separated mice under long-term group-housing conditions are largely unknown. In this study, we applied our newly developed assay system to investigate the effects of maternal separation on behaviours under group-housing conditions during four days of continuous observations. Using our system, we found that repeated maternal separation resulted in inappropriate social distance from cagemates, altered approach preferences to others, and induced a lower rank in the time spent on the running wheel under group-housing conditions in adult male mice. Focussing on these behavioural abnormalities that appear in an environment with a social context will be important insights to understand the pathogenesis of psychiatric disorders.Nozomi EndoManabu MakinodanTakayo Mannari-SasagawaNoriko Horii-HayashiNami SomayamaTakashi KomoriToshifumi KishimotoMayumi NishiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
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Medicine R Science Q Nozomi Endo Manabu Makinodan Takayo Mannari-Sasagawa Noriko Horii-Hayashi Nami Somayama Takashi Komori Toshifumi Kishimoto Mayumi Nishi The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice |
| description |
Abstract Adverse experience in early life can affect the formation of neuronal circuits during postnatal development and exert long-lasting influences on neural functions that can lead to the development of a variety of psychiatric disorders including depression, anxiety disorders, and post-traumatic stress disorder. Many studies have demonstrated that daily repeated maternal separation, an animal model of early-life stress, can induce impairments in emotional behaviours and cognitive function during adolescence and adulthood. However, the behavioural phenotypes of maternally separated mice under long-term group-housing conditions are largely unknown. In this study, we applied our newly developed assay system to investigate the effects of maternal separation on behaviours under group-housing conditions during four days of continuous observations. Using our system, we found that repeated maternal separation resulted in inappropriate social distance from cagemates, altered approach preferences to others, and induced a lower rank in the time spent on the running wheel under group-housing conditions in adult male mice. Focussing on these behavioural abnormalities that appear in an environment with a social context will be important insights to understand the pathogenesis of psychiatric disorders. |
| format |
article |
| author |
Nozomi Endo Manabu Makinodan Takayo Mannari-Sasagawa Noriko Horii-Hayashi Nami Somayama Takashi Komori Toshifumi Kishimoto Mayumi Nishi |
| author_facet |
Nozomi Endo Manabu Makinodan Takayo Mannari-Sasagawa Noriko Horii-Hayashi Nami Somayama Takashi Komori Toshifumi Kishimoto Mayumi Nishi |
| author_sort |
Nozomi Endo |
| title |
The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice |
| title_short |
The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice |
| title_full |
The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice |
| title_fullStr |
The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice |
| title_full_unstemmed |
The effects of maternal separation on behaviours under social-housing environments in adult male C57BL/6 mice |
| title_sort |
effects of maternal separation on behaviours under social-housing environments in adult male c57bl/6 mice |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a77cd609752841f2b86267da7da70580 |
| work_keys_str_mv |
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