4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients

Abstract HBV infection is recognized as a serious global health problem, and hepatitis B virus infection is a complicated chronic disease leading to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). New biochemical serum markers could be used to advance the diagnosis and prognosis of HBV-asso...

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Autores principales:	Yuanyuan Ren, Lei Yang, Man Li, Jian Wang, Huimin Yan, Ning Ma, Wenxuan Liu, Liqin Wang, Xia Gao, Ping Gao, Tao Li, Dianwu Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a77ce642ed6d44f0b71158a060fa90d3
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spelling	oai:doaj.org-article:a77ce642ed6d44f0b71158a060fa90d32021-12-02T17:08:23Z4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients10.1038/s41598-021-96581-42045-2322https://doaj.org/article/a77ce642ed6d44f0b71158a060fa90d32021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96581-4https://doaj.org/toc/2045-2322Abstract HBV infection is recognized as a serious global health problem, and hepatitis B virus infection is a complicated chronic disease leading to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). New biochemical serum markers could be used to advance the diagnosis and prognosis of HBV-associated liver diseases during the progression of chronic hepatitis B into cirrhosis and HCC. We determined whether the 4210 Da and 1866 Da polypeptides are serum metabolite biomarkers of hepatopathy with hepatitis B virus. A total of 570 subjects were divided into five groups: healthy controls, those with natural clearance, and patients with CHB, LC, and HCC. The 1866 Da and 4210 Da polypeptides were measured by Clin-ToF II MALDI-TOF–MS. There were significant differences in 4210 Da and 1866 Da levels among the five groups (P < 0.001). For the differential diagnosis of CHB from normal liver, the areas under the receiver operating characteristic (ROC) curve of 4210 Da and 1866 Da and their combination via logistic regression were 0.961, 0.849 and 0.967. For the differential diagnosis of LC from CHB, the areas under the ROC curve were 0.695, 0.841 and 0.826. For the differential diagnosis of HCC from CHB, the areas under the ROC curve were 0.744, 0.710 and 0.761, respectively. For the differential diagnosis of HCC from LC, the areas under the ROC curve of 4210 Da and 1866 Da were 0.580 and 0.654. The positive rate of 1866 Da was 45.5% and 69.0% in AFP-negative HCC patients and that of 4210 Da was 60.6% 58.6% in AFP-negative HCC patients of the study HCC vs. CHB and HCC vs. LC. The 4210 Da and 1866 Da polypeptide levels were positively correlated with HBV DNA levels (P < 0.001, r = 0.269; P < 0.001, r = 0.285). The 4210 Da and 1866 Da polypeptides had good diagnostic value for the occurrence and progression of HBV-related chronic hepatitis, liver cirrhosis and hepatocellular carcinoma and could serve to accurately guide treatment management and predict clinical outcomes.Yuanyuan RenLei YangMan LiJian WangHuimin YanNing MaWenxuan LiuLiqin WangXia GaoPing GaoTao LiDianwu LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuanyuan Ren Lei Yang Man Li Jian Wang Huimin Yan Ning Ma Wenxuan Liu Liqin Wang Xia Gao Ping Gao Tao Li Dianwu Liu 4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
description	Abstract HBV infection is recognized as a serious global health problem, and hepatitis B virus infection is a complicated chronic disease leading to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). New biochemical serum markers could be used to advance the diagnosis and prognosis of HBV-associated liver diseases during the progression of chronic hepatitis B into cirrhosis and HCC. We determined whether the 4210 Da and 1866 Da polypeptides are serum metabolite biomarkers of hepatopathy with hepatitis B virus. A total of 570 subjects were divided into five groups: healthy controls, those with natural clearance, and patients with CHB, LC, and HCC. The 1866 Da and 4210 Da polypeptides were measured by Clin-ToF II MALDI-TOF–MS. There were significant differences in 4210 Da and 1866 Da levels among the five groups (P < 0.001). For the differential diagnosis of CHB from normal liver, the areas under the receiver operating characteristic (ROC) curve of 4210 Da and 1866 Da and their combination via logistic regression were 0.961, 0.849 and 0.967. For the differential diagnosis of LC from CHB, the areas under the ROC curve were 0.695, 0.841 and 0.826. For the differential diagnosis of HCC from CHB, the areas under the ROC curve were 0.744, 0.710 and 0.761, respectively. For the differential diagnosis of HCC from LC, the areas under the ROC curve of 4210 Da and 1866 Da were 0.580 and 0.654. The positive rate of 1866 Da was 45.5% and 69.0% in AFP-negative HCC patients and that of 4210 Da was 60.6% 58.6% in AFP-negative HCC patients of the study HCC vs. CHB and HCC vs. LC. The 4210 Da and 1866 Da polypeptide levels were positively correlated with HBV DNA levels (P < 0.001, r = 0.269; P < 0.001, r = 0.285). The 4210 Da and 1866 Da polypeptides had good diagnostic value for the occurrence and progression of HBV-related chronic hepatitis, liver cirrhosis and hepatocellular carcinoma and could serve to accurately guide treatment management and predict clinical outcomes.
format	article
author	Yuanyuan Ren Lei Yang Man Li Jian Wang Huimin Yan Ning Ma Wenxuan Liu Liqin Wang Xia Gao Ping Gao Tao Li Dianwu Liu
author_facet	Yuanyuan Ren Lei Yang Man Li Jian Wang Huimin Yan Ning Ma Wenxuan Liu Liqin Wang Xia Gao Ping Gao Tao Li Dianwu Liu
author_sort	Yuanyuan Ren
title	4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
title_short	4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
title_full	4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
title_fullStr	4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
title_full_unstemmed	4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
title_sort	4210 da and 1866 da polypeptides as potential biomarkers of liver disease progression in hepatitis b virus patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a77ce642ed6d44f0b71158a060fa90d3
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4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients

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