Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat

Abstract The aim of the study was the detection of TRP, kynurenine (KYN), and kynurenic acid (KYNA) in human sweat, and determining whether physical activity affects their content in this secrete. Two different methods were used simultaneously—collection of sweat by means of an absorption pad from t...

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Autores principales:	Tomasz Saran, Monika Turska, Tomasz Kocki, Magdalena Zawadka, Grzegorz Zieliński, Waldemar A. Turski, Piotr Gawda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a77f3daaeb304f878b1f7e4c78ea6089
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spelling	oai:doaj.org-article:a77f3daaeb304f878b1f7e4c78ea60892021-12-02T15:49:39ZEffect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat10.1038/s41598-021-90616-62045-2322https://doaj.org/article/a77f3daaeb304f878b1f7e4c78ea60892021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90616-6https://doaj.org/toc/2045-2322Abstract The aim of the study was the detection of TRP, kynurenine (KYN), and kynurenic acid (KYNA) in human sweat, and determining whether physical activity affects their content in this secrete. Two different methods were used simultaneously—collection of sweat by means of an absorption pad from the inter scapular region, and collection of a drop of sweat from the region of the forehead. Quantitative determinations of TRP, KYN and KYNA were performed using high performance liquid chromatography with ultraviolet and fluorescence detection. Determinations of sodium was carried out by the method of inductively coupled plasma collision/reaction cell ionization mass spectrophotometry. It was found that physical exercises evoked a decrease in the amount of KYN, and an increase in the amount of KYNA in sweat recorded on day 14, but not on day 28 of training. It appears that physical exercises result in a long-term increase in the kynurenine transaminase activity responsible for the formation of KYNA from KYN. Based on this results, it can be suggested that measurement of TRP, KYN and KYNA in sweat may have diagnostic potential and may help to establish an exercise regime appropriate for the age, gender and health status of rehabilitation patients.Tomasz SaranMonika TurskaTomasz KockiMagdalena ZawadkaGrzegorz ZielińskiWaldemar A. TurskiPiotr GawdaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomasz Saran Monika Turska Tomasz Kocki Magdalena Zawadka Grzegorz Zieliński Waldemar A. Turski Piotr Gawda Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
description	Abstract The aim of the study was the detection of TRP, kynurenine (KYN), and kynurenic acid (KYNA) in human sweat, and determining whether physical activity affects their content in this secrete. Two different methods were used simultaneously—collection of sweat by means of an absorption pad from the inter scapular region, and collection of a drop of sweat from the region of the forehead. Quantitative determinations of TRP, KYN and KYNA were performed using high performance liquid chromatography with ultraviolet and fluorescence detection. Determinations of sodium was carried out by the method of inductively coupled plasma collision/reaction cell ionization mass spectrophotometry. It was found that physical exercises evoked a decrease in the amount of KYN, and an increase in the amount of KYNA in sweat recorded on day 14, but not on day 28 of training. It appears that physical exercises result in a long-term increase in the kynurenine transaminase activity responsible for the formation of KYNA from KYN. Based on this results, it can be suggested that measurement of TRP, KYN and KYNA in sweat may have diagnostic potential and may help to establish an exercise regime appropriate for the age, gender and health status of rehabilitation patients.
format	article
author	Tomasz Saran Monika Turska Tomasz Kocki Magdalena Zawadka Grzegorz Zieliński Waldemar A. Turski Piotr Gawda
author_facet	Tomasz Saran Monika Turska Tomasz Kocki Magdalena Zawadka Grzegorz Zieliński Waldemar A. Turski Piotr Gawda
author_sort	Tomasz Saran
title	Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_short	Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_full	Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_fullStr	Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_full_unstemmed	Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
title_sort	effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a77f3daaeb304f878b1f7e4c78ea6089
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Effect of 4-week physical exercises on tryptophan, kynurenine and kynurenic acid content in human sweat

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