Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.

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Detalles Bibliográficos
Autores principales: Yi Zhang, Younghoon Jang, Ji-Eun Lee, JaeWoo Ahn, Longxia Xu, Michael R. Holden, Evan M. Cornett, Krzysztof Krajewski, Brianna J. Klein, Shu-Ping Wang, Yali Dou, Robert G. Roeder, Brian D. Strahl, Scott B. Rothbart, Xiaobing Shi, Kai Ge, Tatiana G. Kutateladze
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/a7801b7cee2a472f82747f0b8a567101
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Descripción
Sumario:Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.

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