Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.

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Autores principales:	Yi Zhang, Younghoon Jang, Ji-Eun Lee, JaeWoo Ahn, Longxia Xu, Michael R. Holden, Evan M. Cornett, Krzysztof Krajewski, Brianna J. Klein, Shu-Ping Wang, Yali Dou, Robert G. Roeder, Brian D. Strahl, Scott B. Rothbart, Xiaobing Shi, Kai Ge, Tatiana G. Kutateladze
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a7801b7cee2a472f82747f0b8a567101
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spelling	oai:doaj.org-article:a7801b7cee2a472f82747f0b8a5671012021-12-02T17:01:59ZSelective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF10.1038/s41467-019-10324-82041-1723https://doaj.org/article/a7801b7cee2a472f82747f0b8a5671012019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10324-8https://doaj.org/toc/2041-1723Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.Yi ZhangYounghoon JangJi-Eun LeeJaeWoo AhnLongxia XuMichael R. HoldenEvan M. CornettKrzysztof KrajewskiBrianna J. KleinShu-Ping WangYali DouRobert G. RoederBrian D. StrahlScott B. RothbartXiaobing ShiKai GeTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Zhang Younghoon Jang Ji-Eun Lee JaeWoo Ahn Longxia Xu Michael R. Holden Evan M. Cornett Krzysztof Krajewski Brianna J. Klein Shu-Ping Wang Yali Dou Robert G. Roeder Brian D. Strahl Scott B. Rothbart Xiaobing Shi Kai Ge Tatiana G. Kutateladze Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
description	Histone methyltransferase MLL4 is a transcriptional regulator. Here the authors identify the PHD6 finger of MLL4 as a selective reader of the epigenetic modification H4K16ac and show that a subset of MLL4 chromatin binding sites overlap with H4K16ac-enriched regions, which depends on MOF activity.
format	article
author	Yi Zhang Younghoon Jang Ji-Eun Lee JaeWoo Ahn Longxia Xu Michael R. Holden Evan M. Cornett Krzysztof Krajewski Brianna J. Klein Shu-Ping Wang Yali Dou Robert G. Roeder Brian D. Strahl Scott B. Rothbart Xiaobing Shi Kai Ge Tatiana G. Kutateladze
author_facet	Yi Zhang Younghoon Jang Ji-Eun Lee JaeWoo Ahn Longxia Xu Michael R. Holden Evan M. Cornett Krzysztof Krajewski Brianna J. Klein Shu-Ping Wang Yali Dou Robert G. Roeder Brian D. Strahl Scott B. Rothbart Xiaobing Shi Kai Ge Tatiana G. Kutateladze
author_sort	Yi Zhang
title	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
title_short	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
title_full	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
title_fullStr	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
title_full_unstemmed	Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF
title_sort	selective binding of the phd6 finger of mll4 to histone h4k16ac links mll4 and mof
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a7801b7cee2a472f82747f0b8a567101
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Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF

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