Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques
Abstract The thermo-mechanical properties of streptavidin-conjugated gold nanospheres, adhered to a surface via complex molecular chains, are investigated by two-color infrared asynchronous optical sampling pump-probe spectroscopy. Nanospheres with different surface densities have been deposited and...
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Nature Portfolio
2020
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oai:doaj.org-article:a78090df44534117a9999e54c39290b42021-12-02T18:51:35ZOptical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques10.1038/s41598-020-72534-12045-2322https://doaj.org/article/a78090df44534117a9999e54c39290b42020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72534-1https://doaj.org/toc/2045-2322Abstract The thermo-mechanical properties of streptavidin-conjugated gold nanospheres, adhered to a surface via complex molecular chains, are investigated by two-color infrared asynchronous optical sampling pump-probe spectroscopy. Nanospheres with different surface densities have been deposited and exposed to a plasma treatment to modify their polymer binding chains. The aim is to monitor their optical response in complex chemical environments that may be experienced in, e.g., photothermal therapy or drug delivery applications. By applying unsupervised learning techniques to the spectroscopic traces, we identify their thermo-mechanical response variation. This variation discriminates nanospheres in different chemical environments or different surface densities. Such discrimination is not evident based on a standard analysis of the spectroscopic traces. This kind of analysis is important, given the widespread application of conjugated gold nanospheres in medicine and biology.Simone PeliAndrea RonchiGiada BianchettiFrancesco RossellaClaudio GiannettiMarcella ChiariPasqualantonio PingueFrancesco BanfiGabriele FerriniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020) |
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DOAJ |
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DOAJ |
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EN |
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Medicine R Science Q |
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Medicine R Science Q Simone Peli Andrea Ronchi Giada Bianchetti Francesco Rossella Claudio Giannetti Marcella Chiari Pasqualantonio Pingue Francesco Banfi Gabriele Ferrini Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques |
| description |
Abstract The thermo-mechanical properties of streptavidin-conjugated gold nanospheres, adhered to a surface via complex molecular chains, are investigated by two-color infrared asynchronous optical sampling pump-probe spectroscopy. Nanospheres with different surface densities have been deposited and exposed to a plasma treatment to modify their polymer binding chains. The aim is to monitor their optical response in complex chemical environments that may be experienced in, e.g., photothermal therapy or drug delivery applications. By applying unsupervised learning techniques to the spectroscopic traces, we identify their thermo-mechanical response variation. This variation discriminates nanospheres in different chemical environments or different surface densities. Such discrimination is not evident based on a standard analysis of the spectroscopic traces. This kind of analysis is important, given the widespread application of conjugated gold nanospheres in medicine and biology. |
| format |
article |
| author |
Simone Peli Andrea Ronchi Giada Bianchetti Francesco Rossella Claudio Giannetti Marcella Chiari Pasqualantonio Pingue Francesco Banfi Gabriele Ferrini |
| author_facet |
Simone Peli Andrea Ronchi Giada Bianchetti Francesco Rossella Claudio Giannetti Marcella Chiari Pasqualantonio Pingue Francesco Banfi Gabriele Ferrini |
| author_sort |
Simone Peli |
| title |
Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques |
| title_short |
Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques |
| title_full |
Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques |
| title_fullStr |
Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques |
| title_full_unstemmed |
Optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques |
| title_sort |
optical and mechanical properties of streptavidin-conjugated gold nanospheres through data mining techniques |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/a78090df44534117a9999e54c39290b4 |
| work_keys_str_mv |
AT simonepeli opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT andrearonchi opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT giadabianchetti opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT francescorossella opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT claudiogiannetti opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT marcellachiari opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT pasqualantoniopingue opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT francescobanfi opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques AT gabrieleferrini opticalandmechanicalpropertiesofstreptavidinconjugatedgoldnanospheresthroughdataminingtechniques |
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1718377402434846720 |