IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

The study was devoted to development of non-invasive methods for diagnosis of liver fibrosis in patients with chronic viral hepatitis (CVH). The stepwise logistic multivariate regression analysis of biochemical (PTI, glucose, albumin, AST, LDH) and immunological parameters (the functional activity o...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M. V. Shipunov, N. M. Starostina, E. L. Gelfgadt, E. R. Chernykh, A. A. Ostanin
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	chronic virus hepatitis fibrosis stages non-invasive diagnostics Science Q
Acceso en línea:	https://doaj.org/article/a783901bdef3480fa2121ee279c2106c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a783901bdef3480fa2121ee279c2106c
record_format	dspace
spelling	oai:doaj.org-article:a783901bdef3480fa2121ee279c2106c2021-11-23T06:14:19ZIMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS2541-94202587-9596https://doaj.org/article/a783901bdef3480fa2121ee279c2106c2012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/924https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The study was devoted to development of non-invasive methods for diagnosis of liver fibrosis in patients with chronic viral hepatitis (CVH). The stepwise logistic multivariate regression analysis of biochemical (PTI, glucose, albumin, AST, LDH) and immunological parameters (the functional activity of neutrophils and monocytes, the relative content of CD8+ T- and CD19+B-cells) was used for the establishment of diagnostic model. Based on the multiple regression analysis we derived a 2 novel Integral Indexes of Liver Fibrosis (IILF-biochem and IILF-immun, respectively). It is shown that IILF-biochem allows, without resorting to liver biopsy to predict the appropriate stage of fibrosis in CHV patients with diagnostic accuracy of 86—87 %, and in combination with IILF — at 97.7 %.M. V. ShipunovN. M. StarostinaE. L. GelfgadtE. R. ChernykhA. A. OstaninScientific Сentre for Family Health and Human Reproduction Problemsarticlechronic virus hepatitisfibrosis stagesnon-invasive diagnosticsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 231-236 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic virus hepatitis fibrosis stages non-invasive diagnostics Science Q
spellingShingle	chronic virus hepatitis fibrosis stages non-invasive diagnostics Science Q M. V. Shipunov N. M. Starostina E. L. Gelfgadt E. R. Chernykh A. A. Ostanin IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
description	The study was devoted to development of non-invasive methods for diagnosis of liver fibrosis in patients with chronic viral hepatitis (CVH). The stepwise logistic multivariate regression analysis of biochemical (PTI, glucose, albumin, AST, LDH) and immunological parameters (the functional activity of neutrophils and monocytes, the relative content of CD8+ T- and CD19+B-cells) was used for the establishment of diagnostic model. Based on the multiple regression analysis we derived a 2 novel Integral Indexes of Liver Fibrosis (IILF-biochem and IILF-immun, respectively). It is shown that IILF-biochem allows, without resorting to liver biopsy to predict the appropriate stage of fibrosis in CHV patients with diagnostic accuracy of 86—87 %, and in combination with IILF — at 97.7 %.
format	article
author	M. V. Shipunov N. M. Starostina E. L. Gelfgadt E. R. Chernykh A. A. Ostanin
author_facet	M. V. Shipunov N. M. Starostina E. L. Gelfgadt E. R. Chernykh A. A. Ostanin
author_sort	M. V. Shipunov
title	IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_short	IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_full	IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_fullStr	IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_full_unstemmed	IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS
title_sort	immune predictors of fibrogenesis and their application for non-invasive diagnostics of liver fibrosis in patients with chronic viral hepatitis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/a783901bdef3480fa2121ee279c2106c
work_keys_str_mv	AT mvshipunov immunepredictorsoffibrogenesisandtheirapplicationfornoninvasivediagnosticsofliverfibrosisinpatientswithchronicviralhepatitis AT nmstarostina immunepredictorsoffibrogenesisandtheirapplicationfornoninvasivediagnosticsofliverfibrosisinpatientswithchronicviralhepatitis AT elgelfgadt immunepredictorsoffibrogenesisandtheirapplicationfornoninvasivediagnosticsofliverfibrosisinpatientswithchronicviralhepatitis AT erchernykh immunepredictorsoffibrogenesisandtheirapplicationfornoninvasivediagnosticsofliverfibrosisinpatientswithchronicviralhepatitis AT aaostanin immunepredictorsoffibrogenesisandtheirapplicationfornoninvasivediagnosticsofliverfibrosisinpatientswithchronicviralhepatitis
_version_	1718417270569435136

IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

Ejemplares similares