Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Social impairment and anhedonia are common negative symptoms in patients with schizophrenia. Here, the authors show that the histamine H1 receptor in cholinergic neurons in the basal forebrain has a critical role in sensorimotor gating, social behaviour, and anhedonia-like behaviour in mice.

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Autores principales:	Li Cheng, Cenglin Xu, Lu Wang, Dadao An, Lei Jiang, Yanrong Zheng, Yixin Xu, Yi Wang, Yujing Wang, Kuo Zhang, Xiaodong Wang, Xiangnan Zhang, Aimin Bao, Yudong Zhou, Jingyu Yang, Shumin Duan, Dick F. Swaab, Weiwei Hu, Zhong Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a784f8fd02d24f0898a211da04d363c4
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spelling	oai:doaj.org-article:a784f8fd02d24f0898a211da04d363c42021-12-02T14:21:20ZHistamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice10.1038/s41467-021-21476-x2041-1723https://doaj.org/article/a784f8fd02d24f0898a211da04d363c42021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21476-xhttps://doaj.org/toc/2041-1723Social impairment and anhedonia are common negative symptoms in patients with schizophrenia. Here, the authors show that the histamine H1 receptor in cholinergic neurons in the basal forebrain has a critical role in sensorimotor gating, social behaviour, and anhedonia-like behaviour in mice.Li ChengCenglin XuLu WangDadao AnLei JiangYanrong ZhengYixin XuYi WangYujing WangKuo ZhangXiaodong WangXiangnan ZhangAimin BaoYudong ZhouJingyu YangShumin DuanDick F. SwaabWeiwei HuZhong ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Cheng Cenglin Xu Lu Wang Dadao An Lei Jiang Yanrong Zheng Yixin Xu Yi Wang Yujing Wang Kuo Zhang Xiaodong Wang Xiangnan Zhang Aimin Bao Yudong Zhou Jingyu Yang Shumin Duan Dick F. Swaab Weiwei Hu Zhong Chen Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
description	Social impairment and anhedonia are common negative symptoms in patients with schizophrenia. Here, the authors show that the histamine H1 receptor in cholinergic neurons in the basal forebrain has a critical role in sensorimotor gating, social behaviour, and anhedonia-like behaviour in mice.
format	article
author	Li Cheng Cenglin Xu Lu Wang Dadao An Lei Jiang Yanrong Zheng Yixin Xu Yi Wang Yujing Wang Kuo Zhang Xiaodong Wang Xiangnan Zhang Aimin Bao Yudong Zhou Jingyu Yang Shumin Duan Dick F. Swaab Weiwei Hu Zhong Chen
author_facet	Li Cheng Cenglin Xu Lu Wang Dadao An Lei Jiang Yanrong Zheng Yixin Xu Yi Wang Yujing Wang Kuo Zhang Xiaodong Wang Xiangnan Zhang Aimin Bao Yudong Zhou Jingyu Yang Shumin Duan Dick F. Swaab Weiwei Hu Zhong Chen
author_sort	Li Cheng
title	Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
title_short	Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
title_full	Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
title_fullStr	Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
title_full_unstemmed	Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
title_sort	histamine h1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a784f8fd02d24f0898a211da04d363c4
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Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

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