Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge
The small molecule Nobiletin enhances circadian rhythms and protects against obesity-associated metabolic dysfunction in mice. Here the authors test its effect on health and lifespan, reporting that circadian enhancement promotes fitness and healthy aging in metabolically challenged mice.
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Nature Portfolio
2019
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oai:doaj.org-article:a785be3a47764eeebef82872ff3d00a82021-12-02T16:58:15ZNobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge10.1038/s41467-019-11926-y2041-1723https://doaj.org/article/a785be3a47764eeebef82872ff3d00a82019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11926-yhttps://doaj.org/toc/2041-1723The small molecule Nobiletin enhances circadian rhythms and protects against obesity-associated metabolic dysfunction in mice. Here the authors test its effect on health and lifespan, reporting that circadian enhancement promotes fitness and healthy aging in metabolically challenged mice.Kazunari NoharaVenkata MallampalliTravis NemkovMarvin WiriantoJiah YangYouqiong YeYuxiang SunLeng HanKaryn A. EsserEugenia MileykovskayaAngelo D’AlessandroCarla B. GreenJoseph S. TakahashiWilliam DowhanSeung-Hee YooZheng ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kazunari Nohara Venkata Mallampalli Travis Nemkov Marvin Wirianto Jiah Yang Youqiong Ye Yuxiang Sun Leng Han Karyn A. Esser Eugenia Mileykovskaya Angelo D’Alessandro Carla B. Green Joseph S. Takahashi William Dowhan Seung-Hee Yoo Zheng Chen Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge |
| description |
The small molecule Nobiletin enhances circadian rhythms and protects against obesity-associated metabolic dysfunction in mice. Here the authors test its effect on health and lifespan, reporting that circadian enhancement promotes fitness and healthy aging in metabolically challenged mice. |
| format |
article |
| author |
Kazunari Nohara Venkata Mallampalli Travis Nemkov Marvin Wirianto Jiah Yang Youqiong Ye Yuxiang Sun Leng Han Karyn A. Esser Eugenia Mileykovskaya Angelo D’Alessandro Carla B. Green Joseph S. Takahashi William Dowhan Seung-Hee Yoo Zheng Chen |
| author_facet |
Kazunari Nohara Venkata Mallampalli Travis Nemkov Marvin Wirianto Jiah Yang Youqiong Ye Yuxiang Sun Leng Han Karyn A. Esser Eugenia Mileykovskaya Angelo D’Alessandro Carla B. Green Joseph S. Takahashi William Dowhan Seung-Hee Yoo Zheng Chen |
| author_sort |
Kazunari Nohara |
| title |
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge |
| title_short |
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge |
| title_full |
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge |
| title_fullStr |
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge |
| title_full_unstemmed |
Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge |
| title_sort |
nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/a785be3a47764eeebef82872ff3d00a8 |
| work_keys_str_mv |
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