IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm

Joanna Kami&nacute;ska,1 Violetta Dymicka-Piekarska,1 Robert Chrzanowski,2 Karol Sawicki,2 Anna J Milewska,3 Justyna Zi&nacute;czuk,1 Marzena Tylicka,4 Marek Jadeszko,2 Zenon Mariak,2 Ewa M Kratz,5 Joanna Matowicka-Karna,1 Johannes Kornhuber,6 Piotr Lewczuk,6,7 Olga M Koper-Lenkiewicz1 1Depa...

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Autores principales:	Kamińska J, Dymicka-Piekarska V, Chrzanowski R, Sawicki K, Milewska AJ, Zińczuk J, Tylicka M, Jadeszko M, Mariak Z, Kratz EM, Matowicka-Karna J, Kornhuber J, Lewczuk P, Koper-Lenkiewicz OM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	cerebrospinal fluid (csf) interleukin 6 (il-6) unruptured intracranial aneurysm (uia) il-6 quotient Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a787dfe5c6984e8085d72886c8b196ba
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spelling	oai:doaj.org-article:a787dfe5c6984e8085d72886c8b196ba2021-11-23T18:43:01ZIL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm1178-7031https://doaj.org/article/a787dfe5c6984e8085d72886c8b196ba2021-11-01T00:00:00Zhttps://www.dovepress.com/il-6-quotient-the-ratio-of-cerebrospinal-fluid-il-6-to-serum-il-6-as-a-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Joanna Kami&nacute;ska,1 Violetta Dymicka-Piekarska,1 Robert Chrzanowski,2 Karol Sawicki,2 Anna J Milewska,3 Justyna Zi&nacute;czuk,1 Marzena Tylicka,4 Marek Jadeszko,2 Zenon Mariak,2 Ewa M Kratz,5 Joanna Matowicka-Karna,1 Johannes Kornhuber,6 Piotr Lewczuk,6,7 Olga M Koper-Lenkiewicz1 1Department of Clinical Laboratory Diagnostics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-269, Poland; 2Department of Neurosurgery, Clinical Hospital of the Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-276, Poland; 3Department of Statistics and Medical Informatics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-295, Poland; 4Department of Biophysics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-089, Poland; 5Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroc&lstrok;aw Medical University, Wroc&lstrok;aw, 50-556, Poland; 6Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, 91054, Germany; 7Department of Neurodegeneration Diagnostics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-269, PolandCorrespondence: Joanna Kami&nacute;ska; Olga M Koper-LenkiewiczDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 15A St., Bia&lstrok;ystok, 15-269, PolandTel/Fax +48 85 7468584Email joanna.kaminska@umb.edu.pl; o.koper@wp.plBackground: Studies conducted so far have focused mainly on the assessment of IL-6 levels in patients with ruptured brain aneurysms. Carrying out detailed studies in patients with un-ruptured brain aneurysms (UIA) would be extremely important, as it would answer the question of whether IL-6 plays also a role in primary aneurysm formation and growth.Methods: IL-6, S100, NSE, and albumin concentrations in 67 UIA patients and 17 individuals without vascular lesions in the brain were tested using in vitro diagnostic immunoassays according to the manufacturers’ instructions. IL-6 Quotient was calculated by dividing cerebrospinal fluid (CSF) IL-6 by serum IL-6.Results: We showed that IL-6 Quotient was significantly higher in UIA patients (1.78) compared to the control group (0.87; p< 0.001). Multivariate logistic regression analysis demonstrated that a growth in IL-6 Quotient increases the probability of UIA diagnosis. In UIA patients CSF IL-6 concentration was significantly higher (4.55 pg/ml) compared to the serum concentration (2.39 pg/ml; p< 0.001). In both the study and control group, the blood-brain barrier was intact, thus the CSF-blood gradient of the IL-6 concentration in UIA patients was likely to be the expression of local synthesis of the cytokine within the central nervous system. Patients with multiple brain aneurysms had significantly higher CSF IL-6 levels (5.08 pg/ml) compared to individuals with a single aneurysm (4.14 pg/ml; p=0.0227).Conclusion: This totality of the may suggest IL-6 as a biomarker for UIA formation; however, further studies are needed to unequivocally confirm clinical application of IL-6 concentration evaluation.Keywords: cerebrospinal fluid, CSF, interleukin 6, IL-6, unruptured intracranial aneurysm, UIA, IL-6 QuotientKamińska JDymicka-Piekarska VChrzanowski RSawicki KMilewska AJZińczuk JTylicka MJadeszko MMariak ZKratz EMMatowicka-Karna JKornhuber JLewczuk PKoper-Lenkiewicz OMDove Medical Pressarticlecerebrospinal fluid (csf)interleukin 6 (il-6)unruptured intracranial aneurysm (uia)il-6 quotientPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 6103-6114 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerebrospinal fluid (csf) interleukin 6 (il-6) unruptured intracranial aneurysm (uia) il-6 quotient Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	cerebrospinal fluid (csf) interleukin 6 (il-6) unruptured intracranial aneurysm (uia) il-6 quotient Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Kamińska J Dymicka-Piekarska V Chrzanowski R Sawicki K Milewska AJ Zińczuk J Tylicka M Jadeszko M Mariak Z Kratz EM Matowicka-Karna J Kornhuber J Lewczuk P Koper-Lenkiewicz OM IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
description	Joanna Kami&nacute;ska,1 Violetta Dymicka-Piekarska,1 Robert Chrzanowski,2 Karol Sawicki,2 Anna J Milewska,3 Justyna Zi&nacute;czuk,1 Marzena Tylicka,4 Marek Jadeszko,2 Zenon Mariak,2 Ewa M Kratz,5 Joanna Matowicka-Karna,1 Johannes Kornhuber,6 Piotr Lewczuk,6,7 Olga M Koper-Lenkiewicz1 1Department of Clinical Laboratory Diagnostics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-269, Poland; 2Department of Neurosurgery, Clinical Hospital of the Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-276, Poland; 3Department of Statistics and Medical Informatics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-295, Poland; 4Department of Biophysics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-089, Poland; 5Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroc&lstrok;aw Medical University, Wroc&lstrok;aw, 50-556, Poland; 6Department of Psychiatry and Psychotherapy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, 91054, Germany; 7Department of Neurodegeneration Diagnostics, Medical University of Bia&lstrok;ystok, Bia&lstrok;ystok, 15-269, PolandCorrespondence: Joanna Kami&nacute;ska; Olga M Koper-LenkiewiczDepartment of Clinical Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 15A St., Bia&lstrok;ystok, 15-269, PolandTel/Fax +48 85 7468584Email joanna.kaminska@umb.edu.pl; o.koper@wp.plBackground: Studies conducted so far have focused mainly on the assessment of IL-6 levels in patients with ruptured brain aneurysms. Carrying out detailed studies in patients with un-ruptured brain aneurysms (UIA) would be extremely important, as it would answer the question of whether IL-6 plays also a role in primary aneurysm formation and growth.Methods: IL-6, S100, NSE, and albumin concentrations in 67 UIA patients and 17 individuals without vascular lesions in the brain were tested using in vitro diagnostic immunoassays according to the manufacturers’ instructions. IL-6 Quotient was calculated by dividing cerebrospinal fluid (CSF) IL-6 by serum IL-6.Results: We showed that IL-6 Quotient was significantly higher in UIA patients (1.78) compared to the control group (0.87; p< 0.001). Multivariate logistic regression analysis demonstrated that a growth in IL-6 Quotient increases the probability of UIA diagnosis. In UIA patients CSF IL-6 concentration was significantly higher (4.55 pg/ml) compared to the serum concentration (2.39 pg/ml; p< 0.001). In both the study and control group, the blood-brain barrier was intact, thus the CSF-blood gradient of the IL-6 concentration in UIA patients was likely to be the expression of local synthesis of the cytokine within the central nervous system. Patients with multiple brain aneurysms had significantly higher CSF IL-6 levels (5.08 pg/ml) compared to individuals with a single aneurysm (4.14 pg/ml; p=0.0227).Conclusion: This totality of the may suggest IL-6 as a biomarker for UIA formation; however, further studies are needed to unequivocally confirm clinical application of IL-6 concentration evaluation.Keywords: cerebrospinal fluid, CSF, interleukin 6, IL-6, unruptured intracranial aneurysm, UIA, IL-6 Quotient
format	article
author	Kamińska J Dymicka-Piekarska V Chrzanowski R Sawicki K Milewska AJ Zińczuk J Tylicka M Jadeszko M Mariak Z Kratz EM Matowicka-Karna J Kornhuber J Lewczuk P Koper-Lenkiewicz OM
author_facet	Kamińska J Dymicka-Piekarska V Chrzanowski R Sawicki K Milewska AJ Zińczuk J Tylicka M Jadeszko M Mariak Z Kratz EM Matowicka-Karna J Kornhuber J Lewczuk P Koper-Lenkiewicz OM
author_sort	Kamińska J
title	IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
title_short	IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
title_full	IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
title_fullStr	IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
title_full_unstemmed	IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm
title_sort	il-6 quotient (the ratio of cerebrospinal fluid il-6 to serum il-6) as a biomarker of an unruptured intracranial aneurysm
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a787dfe5c6984e8085d72886c8b196ba
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IL-6 Quotient (The Ratio of Cerebrospinal Fluid IL-6 to Serum IL-6) as a Biomarker of an Unruptured Intracranial Aneurysm

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