Cooperativity dominates the genomic organization of p53-response elements: a mechanistic view.
p53-response elements (p53-REs) are organized as two repeats of a palindromic DNA segment spaced by 0 to 20 base pairs (bp). Several experiments indicate that in the vast majority of the human p53-REs there are no spacers between the two repeats; those with spacers, particularly with sizes beyond tw...
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Autores principales: | Yongping Pan, Ruth Nussinov |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2009
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Materias: | |
Acceso en línea: | https://doaj.org/article/a787ec909db64729904d831aed0305f0 |
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