SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

Cellular senescence—the permanent cessation of cell proliferation—is a process that can be deregulated in cancer and other aging-related diseases. Here the authors demonstrate that the SCFFbxo22-KDM4A complex plays an essential role during senescence as an E3 ligase that targets methylated p53 for d...

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Autores principales:	Yoshikazu Johmura, Jia Sun, Kyoko Kitagawa, Keiko Nakanishi, Toshiya Kuno, Aya Naiki-Ito, Yumi Sawada, Tomomi Miyamoto, Atsushi Okabe, Hiroyuki Aburatani, ShengFan Li, Ichiro Miyoshi, Satoru Takahashi, Masatoshi Kitagawa, Makoto Nakanishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a78817db806f42beac081b69b8dcfa12
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spelling	oai:doaj.org-article:a78817db806f42beac081b69b8dcfa122021-12-02T15:35:42ZSCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence10.1038/ncomms105742041-1723https://doaj.org/article/a78817db806f42beac081b69b8dcfa122016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10574https://doaj.org/toc/2041-1723Cellular senescence—the permanent cessation of cell proliferation—is a process that can be deregulated in cancer and other aging-related diseases. Here the authors demonstrate that the SCFFbxo22-KDM4A complex plays an essential role during senescence as an E3 ligase that targets methylated p53 for degradation.Yoshikazu JohmuraJia SunKyoko KitagawaKeiko NakanishiToshiya KunoAya Naiki-ItoYumi SawadaTomomi MiyamotoAtsushi OkabeHiroyuki AburataniShengFan LiIchiro MiyoshiSatoru TakahashiMasatoshi KitagawaMakoto NakanishiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yoshikazu Johmura Jia Sun Kyoko Kitagawa Keiko Nakanishi Toshiya Kuno Aya Naiki-Ito Yumi Sawada Tomomi Miyamoto Atsushi Okabe Hiroyuki Aburatani ShengFan Li Ichiro Miyoshi Satoru Takahashi Masatoshi Kitagawa Makoto Nakanishi SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
description	Cellular senescence—the permanent cessation of cell proliferation—is a process that can be deregulated in cancer and other aging-related diseases. Here the authors demonstrate that the SCFFbxo22-KDM4A complex plays an essential role during senescence as an E3 ligase that targets methylated p53 for degradation.
format	article
author	Yoshikazu Johmura Jia Sun Kyoko Kitagawa Keiko Nakanishi Toshiya Kuno Aya Naiki-Ito Yumi Sawada Tomomi Miyamoto Atsushi Okabe Hiroyuki Aburatani ShengFan Li Ichiro Miyoshi Satoru Takahashi Masatoshi Kitagawa Makoto Nakanishi
author_facet	Yoshikazu Johmura Jia Sun Kyoko Kitagawa Keiko Nakanishi Toshiya Kuno Aya Naiki-Ito Yumi Sawada Tomomi Miyamoto Atsushi Okabe Hiroyuki Aburatani ShengFan Li Ichiro Miyoshi Satoru Takahashi Masatoshi Kitagawa Makoto Nakanishi
author_sort	Yoshikazu Johmura
title	SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
title_short	SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
title_full	SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
title_fullStr	SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
title_full_unstemmed	SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence
title_sort	scffbxo22-kdm4a targets methylated p53 for degradation and regulates senescence
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a78817db806f42beac081b69b8dcfa12
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SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

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