Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events

ABSTRACT CTnDOT is a 65-kb conjugative transposon that is found in Bacteroides spp., which are one of the more abundant members within the lower human gastrointestinal tract. CTnDOT encodes resistance to the antibiotics erythromycin and tetracycline (Tc). An interesting feature of CTnDOT is that exp...

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Autores principales:	Jillian L. Waters, Abigail A. Salyers
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a7888dc3ff904071b7ba24a17c6cc7f1
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spelling	oai:doaj.org-article:a7888dc3ff904071b7ba24a17c6cc7f12021-11-15T15:42:32ZRegulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events10.1128/mBio.00569-132150-7511https://doaj.org/article/a7888dc3ff904071b7ba24a17c6cc7f12013-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00569-13https://doaj.org/toc/2150-7511ABSTRACT CTnDOT is a 65-kb conjugative transposon that is found in Bacteroides spp., which are one of the more abundant members within the lower human gastrointestinal tract. CTnDOT encodes resistance to the antibiotics erythromycin and tetracycline (Tc). An interesting feature of CTnDOT is that exposure to low levels of Tc induces a cascade of events that ultimately results in CTnDOT conjugative transfer. However, Tc is apparently not a switch that activates transfer but rather a signal that appears to override a series of negative regulators that inhibit premature excision and transfer of CTnDOT. In this minireview, we summarize over 20 years of research that focused on elucidating the highly coordinated regulation of excision, mobilization, and transfer of CTnDOT. IMPORTANCE Bacteroides spp. are abundant commensals in the human colon, but they are also considered opportunistic pathogens, as they can cause life-threatening infections if they should escape the colon. Bacteroides spp. are the most common cause of anaerobic infections and are rather difficult to treat due to the prevalence of antibiotic resistance within this genus. Today over 80% of Bacteroides are resistant to tetracycline (Tc), and a study looking at both clinical and community isolates demonstrated that this resistance was specifically due to the conjugative transposon CTnDOT.Jillian L. WatersAbigail A. SalyersAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 6 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jillian L. Waters Abigail A. Salyers Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events
description	ABSTRACT CTnDOT is a 65-kb conjugative transposon that is found in Bacteroides spp., which are one of the more abundant members within the lower human gastrointestinal tract. CTnDOT encodes resistance to the antibiotics erythromycin and tetracycline (Tc). An interesting feature of CTnDOT is that exposure to low levels of Tc induces a cascade of events that ultimately results in CTnDOT conjugative transfer. However, Tc is apparently not a switch that activates transfer but rather a signal that appears to override a series of negative regulators that inhibit premature excision and transfer of CTnDOT. In this minireview, we summarize over 20 years of research that focused on elucidating the highly coordinated regulation of excision, mobilization, and transfer of CTnDOT. IMPORTANCE Bacteroides spp. are abundant commensals in the human colon, but they are also considered opportunistic pathogens, as they can cause life-threatening infections if they should escape the colon. Bacteroides spp. are the most common cause of anaerobic infections and are rather difficult to treat due to the prevalence of antibiotic resistance within this genus. Today over 80% of Bacteroides are resistant to tetracycline (Tc), and a study looking at both clinical and community isolates demonstrated that this resistance was specifically due to the conjugative transposon CTnDOT.
format	article
author	Jillian L. Waters Abigail A. Salyers
author_facet	Jillian L. Waters Abigail A. Salyers
author_sort	Jillian L. Waters
title	Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events
title_short	Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events
title_full	Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events
title_fullStr	Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events
title_full_unstemmed	Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events
title_sort	regulation of ctndot conjugative transfer is a complex and highly coordinated series of events
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/a7888dc3ff904071b7ba24a17c6cc7f1
work_keys_str_mv	AT jillianlwaters regulationofctndotconjugativetransferisacomplexandhighlycoordinatedseriesofevents AT abigailasalyers regulationofctndotconjugativetransferisacomplexandhighlycoordinatedseriesofevents
_version_	1718427604328906752

Regulation of CTnDOT Conjugative Transfer Is a Complex and Highly Coordinated Series of Events

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