Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations

Ahmed Abdel-Karim El-Massry, Amgad Mostafa Dowidar, Tamer Hamdy Massoud, Baher Guirguis Daoud Tadros Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt Background: Corneal collagen cross-linking (CXL) is the only treatment currently available to...

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Autores principales:	El-Massry AA, Dowidar AM, Massoud TH, Tadros BG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Collagen cross linking progressive keratoconus ultraviolet irradiation wavefront aberrations. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a78b4c9aa69d497fbd24e35109ce1606
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spelling	oai:doaj.org-article:a78b4c9aa69d497fbd24e35109ce16062021-12-02T00:04:04ZEvaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations1177-5483https://doaj.org/article/a78b4c9aa69d497fbd24e35109ce16062017-08-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-the-effect-of-corneal-collagen-cross-linking-for-keratoc-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Ahmed Abdel-Karim El-Massry, Amgad Mostafa Dowidar, Tamer Hamdy Massoud, Baher Guirguis Daoud Tadros Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt Background: Corneal collagen cross-linking (CXL) is the only treatment currently available to arrest the progression of keratoconus. The procedure consists of photopolymerization of stromal collagen fibers induced by combined action of a photosensitizing substance (riboflavin or vitamin B2) and ultraviolet-A light.Purpose: To determine changes in the ocular higher-order aberrations (HOAs) after CXL and its correlation with changes in visual acuity.Design: Prospective interventional study.Subjects and methods: This study was conducted on 30 eyes of 16 patients with progressive keratoconus documented between 2012 and 2014. Patients were treated with epithelium-off CXL and followed for a minimum of 6 months. The following ocular HOAs were measured and analyzed using I-Tracey Aberrometer: coma, trefoil, spherical aberration, astigmatism, and total HOAs.Results: There was statistically significant improvement in uncorrected visual acuity and best-corrected visual acuity between the preoperative and 6-month evaluations (P<0.001). Total HOAs and total coma were statistically significantly reduced at 6 months by 25% and 18%, respectively. Significant improvement was seen in spherical aberration by 8.71% (P<0.001), while no significant change was observed in trefoil and high order astigmatism (P=0.405 and 0.329, respectively). There was a statistically significant change in the average (K) value at the apex between the preoperative values and the 6-month values (P<0.05).Conclusion: Total HOAs, total coma, and spherical aberrations decreased after CXL. Coma has a direct relationship with the improvement of visual function. Keywords: collagen cross-linking, progressive keratoconus, ultraviolet irradiation, wavefront aberrationsEl-Massry AADowidar AMMassoud THTadros BGDove Medical PressarticleCollagen cross linkingprogressive keratoconusultraviolet irradiationwavefront aberrations.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 1461-1469 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Collagen cross linking progressive keratoconus ultraviolet irradiation wavefront aberrations. Ophthalmology RE1-994
spellingShingle	Collagen cross linking progressive keratoconus ultraviolet irradiation wavefront aberrations. Ophthalmology RE1-994 El-Massry AA Dowidar AM Massoud TH Tadros BG Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations
description	Ahmed Abdel-Karim El-Massry, Amgad Mostafa Dowidar, Tamer Hamdy Massoud, Baher Guirguis Daoud Tadros Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria Governorate, Egypt Background: Corneal collagen cross-linking (CXL) is the only treatment currently available to arrest the progression of keratoconus. The procedure consists of photopolymerization of stromal collagen fibers induced by combined action of a photosensitizing substance (riboflavin or vitamin B2) and ultraviolet-A light.Purpose: To determine changes in the ocular higher-order aberrations (HOAs) after CXL and its correlation with changes in visual acuity.Design: Prospective interventional study.Subjects and methods: This study was conducted on 30 eyes of 16 patients with progressive keratoconus documented between 2012 and 2014. Patients were treated with epithelium-off CXL and followed for a minimum of 6 months. The following ocular HOAs were measured and analyzed using I-Tracey Aberrometer: coma, trefoil, spherical aberration, astigmatism, and total HOAs.Results: There was statistically significant improvement in uncorrected visual acuity and best-corrected visual acuity between the preoperative and 6-month evaluations (P<0.001). Total HOAs and total coma were statistically significantly reduced at 6 months by 25% and 18%, respectively. Significant improvement was seen in spherical aberration by 8.71% (P<0.001), while no significant change was observed in trefoil and high order astigmatism (P=0.405 and 0.329, respectively). There was a statistically significant change in the average (K) value at the apex between the preoperative values and the 6-month values (P<0.05).Conclusion: Total HOAs, total coma, and spherical aberrations decreased after CXL. Coma has a direct relationship with the improvement of visual function. Keywords: collagen cross-linking, progressive keratoconus, ultraviolet irradiation, wavefront aberrations
format	article
author	El-Massry AA Dowidar AM Massoud TH Tadros BG
author_facet	El-Massry AA Dowidar AM Massoud TH Tadros BG
author_sort	El-Massry AA
title	Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations
title_short	Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations
title_full	Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations
title_fullStr	Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations
title_full_unstemmed	Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations
title_sort	evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a78b4c9aa69d497fbd24e35109ce1606
work_keys_str_mv	AT elmassryaa evaluationoftheeffectofcornealcollagencrosslinkingforkeratoconusontheocularhigherorderaberrations AT dowidaram evaluationoftheeffectofcornealcollagencrosslinkingforkeratoconusontheocularhigherorderaberrations AT massoudth evaluationoftheeffectofcornealcollagencrosslinkingforkeratoconusontheocularhigherorderaberrations AT tadrosbg evaluationoftheeffectofcornealcollagencrosslinkingforkeratoconusontheocularhigherorderaberrations
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Evaluation of the effect of corneal collagen cross-linking for keratoconus on the ocular higher-order aberrations

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