Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy

Abstract To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 re...

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Autores principales:	Julian A. Luetkens, Anne C. Wolpers, Thomas Beiert, Daniel Kuetting, Darius Dabir, Rami Homsi, Hendrik Meendermann, Natalie Abou Dayé, Vincent Knappe, Morten Karsdal, Signe H. Nielsen, Federica Genovese, Florian Stöckigt, Markus Linhart, Daniel Thomas, Georg Nickenig, Hans H. Schild, Jan W. Schrickel, René P. Andrié
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Catheter Ablation Therapy Late Gadolinium Enhancement (LGE) Relaxin Fibrotic Biomarkers Left Atrial (LA) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a791bc9426054598af890b1907253b3b
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spelling	oai:doaj.org-article:a791bc9426054598af890b1907253b3b2021-12-02T15:08:01ZCardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy10.1038/s41598-018-31916-22045-2322https://doaj.org/article/a791bc9426054598af890b1907253b3b2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31916-2https://doaj.org/toc/2045-2322Abstract To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation times were assessed using CMR. Plasma levels of relaxin, myeloperoxidase and serum levels of matrix metalloproteinase (MMP)-mediated cardiac specific titin fragmentation and MMP-mediated type IV collagen degradation were obtained. Poor outcome was defined by the recurrence of AF during 1-year follow-up. 61 patients were included in final analysis. Twenty (32.8%) patients had recurrence of AF. Patients with a recurrence of AF had a higher percentage of LA LGE (26.7 ± 12.5% vs. 17.0 ± 7.7%; P < 0.001), higher LA T1 relaxation times (856.7 ± 112.2 ms vs. 746.8 ± 91.0 ms; P < 0.001) and higher plasma levels of relaxin (0.69 ± 1.34 pg/ml vs. 0.37 ± 0.88 pg/ml; P = 0.035). In the multivariate Cox regression analysis, poor ablation outcome was best predicted by advanced LGE stage (hazard ratio (HR):5.487; P = 0.001) and T1 relaxation times (HR:1.007; P = 0.001). Pre-procedural CMR is a valuable tool for prediction of poor response to catheter ablation therapy in patients with AF. It offers various imaging techniques for outcome prediction and might be valuable for a better patient selection prior to ablation therapy.Julian A. LuetkensAnne C. WolpersThomas BeiertDaniel KuettingDarius DabirRami HomsiHendrik MeendermannNatalie Abou DayéVincent KnappeMorten KarsdalSigne H. NielsenFederica GenoveseFlorian StöckigtMarkus LinhartDaniel ThomasGeorg NickenigHans H. SchildJan W. SchrickelRené P. AndriéNature PortfolioarticleCatheter Ablation TherapyLate Gadolinium Enhancement (LGE)RelaxinFibrotic BiomarkersLeft Atrial (LA)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Catheter Ablation Therapy Late Gadolinium Enhancement (LGE) Relaxin Fibrotic Biomarkers Left Atrial (LA) Medicine R Science Q
spellingShingle	Catheter Ablation Therapy Late Gadolinium Enhancement (LGE) Relaxin Fibrotic Biomarkers Left Atrial (LA) Medicine R Science Q Julian A. Luetkens Anne C. Wolpers Thomas Beiert Daniel Kuetting Darius Dabir Rami Homsi Hendrik Meendermann Natalie Abou Dayé Vincent Knappe Morten Karsdal Signe H. Nielsen Federica Genovese Florian Stöckigt Markus Linhart Daniel Thomas Georg Nickenig Hans H. Schild Jan W. Schrickel René P. Andrié Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
description	Abstract To determine the pre-procedural value of different fibrotic biomarkers and comprehensive cardiac magnetic resonance (CMR) for the prediction of poor response to ablation therapy in patients with atrial fibrillation (AF). Left atrial (LA) late gadolinium enhancement (LGE) and native LA T1 relaxation times were assessed using CMR. Plasma levels of relaxin, myeloperoxidase and serum levels of matrix metalloproteinase (MMP)-mediated cardiac specific titin fragmentation and MMP-mediated type IV collagen degradation were obtained. Poor outcome was defined by the recurrence of AF during 1-year follow-up. 61 patients were included in final analysis. Twenty (32.8%) patients had recurrence of AF. Patients with a recurrence of AF had a higher percentage of LA LGE (26.7 ± 12.5% vs. 17.0 ± 7.7%; P < 0.001), higher LA T1 relaxation times (856.7 ± 112.2 ms vs. 746.8 ± 91.0 ms; P < 0.001) and higher plasma levels of relaxin (0.69 ± 1.34 pg/ml vs. 0.37 ± 0.88 pg/ml; P = 0.035). In the multivariate Cox regression analysis, poor ablation outcome was best predicted by advanced LGE stage (hazard ratio (HR):5.487; P = 0.001) and T1 relaxation times (HR:1.007; P = 0.001). Pre-procedural CMR is a valuable tool for prediction of poor response to catheter ablation therapy in patients with AF. It offers various imaging techniques for outcome prediction and might be valuable for a better patient selection prior to ablation therapy.
format	article
author	Julian A. Luetkens Anne C. Wolpers Thomas Beiert Daniel Kuetting Darius Dabir Rami Homsi Hendrik Meendermann Natalie Abou Dayé Vincent Knappe Morten Karsdal Signe H. Nielsen Federica Genovese Florian Stöckigt Markus Linhart Daniel Thomas Georg Nickenig Hans H. Schild Jan W. Schrickel René P. Andrié
author_facet	Julian A. Luetkens Anne C. Wolpers Thomas Beiert Daniel Kuetting Darius Dabir Rami Homsi Hendrik Meendermann Natalie Abou Dayé Vincent Knappe Morten Karsdal Signe H. Nielsen Federica Genovese Florian Stöckigt Markus Linhart Daniel Thomas Georg Nickenig Hans H. Schild Jan W. Schrickel René P. Andrié
author_sort	Julian A. Luetkens
title	Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
title_short	Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
title_full	Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
title_fullStr	Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
title_full_unstemmed	Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
title_sort	cardiac magnetic resonance using late gadolinium enhancement and atrial t1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a791bc9426054598af890b1907253b3b
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Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy

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