<named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Pyrazinamide Resistance Determinants: a Multicenter Study

<named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Pyrazinamide Resistance Determinants: a Multicenter Study

ABSTRACT Pyrazinamide (PZA) is a prodrug that is converted to pyrazinoic acid by the enzyme pyrazinamidase, encoded by the pncA gene in Mycobacterium tuberculosis. Molecular identification of mutations in pncA offers the potential for rapid detection of pyrazinamide resistance (PZAr). However, the g...

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Bibliographic Details
Main Authors: Paolo Miotto, Andrea M. Cabibbe, Silke Feuerriegel, Nicola Casali, Francis Drobniewski, Yulia Rodionova, Daiva Bakonyte, Petras Stakenas, Edita Pimkina, Ewa Augustynowicz-Kopeć, Massimo Degano, Alessandro Ambrosi, Sven Hoffner, Mikael Mansjö, Jim Werngren, Sabine Rüsch-Gerdes, Stefan Niemann, Daniela M. Cirillo
Format: article
Language:EN
Published: American Society for Microbiology 2014
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/a793c5931b3743058afca8d56f3a8e4d
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