A computationally designed water-soluble variant of a G-protein-coupled receptor: the human mu opioid receptor.

A computationally designed water-soluble variant of a G-protein-coupled receptor: the human mu opioid receptor.

G-protein-coupled receptors (GPCRs) play essential roles in various physiological processes, and are widely targeted by pharmaceutical drugs. Despite their importance, studying GPCRs has been problematic due to difficulties in isolating large quantities of these membrane proteins in forms that retai...

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Autores principales: Jose Manuel Perez-Aguilar, Jin Xi, Felipe Matsunaga, Xu Cui, Bernard Selling, Jeffery G Saven, Renyu Liu
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a797e88a1fe44c17bc5ab20cd146adaa
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