Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Xiaolie He,* Yanjing Zhu,* Mei Wang, Guoxin Jing, Rongrong Zhu, Shilong Wang Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China *These authors contributed e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	He XL, Zhu YJ, Wang M, Jing GX, Zhu RR, Wang SL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Major depression Curcumin HU-211 Solid Lipid Nanoparticles Dopamine Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a79a205a4dfd47598ba30a199142cb51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a79a205a4dfd47598ba30a199142cb51
record_format	dspace
spelling	oai:doaj.org-article:a79a205a4dfd47598ba30a199142cb512021-12-02T02:48:58ZAntidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression1178-2013https://doaj.org/article/a79a205a4dfd47598ba30a199142cb512016-10-01T00:00:00Zhttps://www.dovepress.com/antidepressant-effects-of-curcumin-and-hu-211-coencapsulated-solid-lip-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiaolie He,* Yanjing Zhu,* Mei Wang, Guoxin Jing, Rongrong Zhu, Shilong Wang Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs) to encapsulate HU-211 and curcumin (Cur). The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211) for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment. Keywords: major depression, curcumin, HU-211, solid lipid nanoparticles, dopamineHe XLZhu YJWang MJing GXZhu RRWang SLDove Medical PressarticleMajor depressionCurcuminHU-211Solid Lipid NanoparticlesDopamineMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4975-4990 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Major depression Curcumin HU-211 Solid Lipid Nanoparticles Dopamine Medicine (General) R5-920
spellingShingle	Major depression Curcumin HU-211 Solid Lipid Nanoparticles Dopamine Medicine (General) R5-920 He XL Zhu YJ Wang M Jing GX Zhu RR Wang SL Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
description	Xiaolie He,* Yanjing Zhu,* Mei Wang, Guoxin Jing, Rongrong Zhu, Shilong Wang Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shanghai, People’s Republic of China *These authors contributed equally to this work Abstract: Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs) to encapsulate HU-211 and curcumin (Cur). The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211) for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment. Keywords: major depression, curcumin, HU-211, solid lipid nanoparticles, dopamine
format	article
author	He XL Zhu YJ Wang M Jing GX Zhu RR Wang SL
author_facet	He XL Zhu YJ Wang M Jing GX Zhu RR Wang SL
author_sort	He XL
title	Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
title_short	Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
title_full	Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
title_fullStr	Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
title_full_unstemmed	Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
title_sort	antidepressant effects of curcumin and hu-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a79a205a4dfd47598ba30a199142cb51
work_keys_str_mv	AT hexl antidepressanteffectsofcurcuminandhu211coencapsulatedsolidlipidnanoparticlesagainstcorticosteroneinducedcellularandanimalmodelsofmajordepression AT zhuyj antidepressanteffectsofcurcuminandhu211coencapsulatedsolidlipidnanoparticlesagainstcorticosteroneinducedcellularandanimalmodelsofmajordepression AT wangm antidepressanteffectsofcurcuminandhu211coencapsulatedsolidlipidnanoparticlesagainstcorticosteroneinducedcellularandanimalmodelsofmajordepression AT jinggx antidepressanteffectsofcurcuminandhu211coencapsulatedsolidlipidnanoparticlesagainstcorticosteroneinducedcellularandanimalmodelsofmajordepression AT zhurr antidepressanteffectsofcurcuminandhu211coencapsulatedsolidlipidnanoparticlesagainstcorticosteroneinducedcellularandanimalmodelsofmajordepression AT wangsl antidepressanteffectsofcurcuminandhu211coencapsulatedsolidlipidnanoparticlesagainstcorticosteroneinducedcellularandanimalmodelsofmajordepression
_version_	1718402116280647680

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Ejemplares similares