Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update

The design and development of biosensors, analytical devices used to detect various analytes in different matrices, has emerged. Biosensors indicate a biorecognition element with a physicochemical analyzer or detector, i.e., a transducer. In the present scenario, various types of biosensors have bee...

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Autores principales:	Atul Sharma, Rupesh Kumar Mishra, K. Yugender Goud, Mona A. Mohamed, Shekher Kummari, Swapnil Tiwari, Zhanhong Li, Roger Narayan, Lia A. Stanciu, Jean Louis Marty
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	viral disease optical biosensors diagnostics nanomaterial fluorescence SARS-CoV-2 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a79d1e12682d48cfb98d3e99903e8887
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spelling	oai:doaj.org-article:a79d1e12682d48cfb98d3e99903e88872021-11-25T17:21:29ZOptical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update10.3390/diagnostics111120832075-4418https://doaj.org/article/a79d1e12682d48cfb98d3e99903e88872021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2083https://doaj.org/toc/2075-4418The design and development of biosensors, analytical devices used to detect various analytes in different matrices, has emerged. Biosensors indicate a biorecognition element with a physicochemical analyzer or detector, i.e., a transducer. In the present scenario, various types of biosensors have been deployed in healthcare and clinical research, for instance, biosensors for blood glucose monitoring. Pathogenic microbes are contributing mediators of numerous infectious diseases that are becoming extremely serious worldwide. The recent outbreak of COVID-19 is one of the most recent examples of such communal and deadly diseases. In efforts to work towards the efficacious treatment of pathogenic viral contagions, a fast and precise detection method is of the utmost importance in biomedical and healthcare sectors for early diagnostics and timely countermeasures. Among various available sensor systems, optical biosensors offer easy-to-use, fast, portable, handy, multiplexed, direct, real-time, and inexpensive diagnosis with the added advantages of specificity and sensitivity. Many progressive concepts and extremely multidisciplinary approaches, including microelectronics, microelectromechanical systems (MEMSs), nanotechnologies, molecular biology, and biotechnology with chemistry, are used to operate optical biosensors. A portable and handheld optical biosensing device would provide fast and reliable results for the identification and quantitation of pathogenic virus particles in each sample. In the modern day, the integration of intelligent nanomaterials in the developed devices provides much more sensitive and highly advanced sensors that may produce the results in no time and eventually help clinicians and doctors enormously. This review accentuates the existing challenges engaged in converting laboratory research to real-world device applications and optical diagnostics methods for virus infections. The review’s background and progress are expected to be insightful to the researchers in the sensor field and facilitate the design and fabrication of optical sensors for life-threatening viruses with broader applicability to any desired pathogens.Atul SharmaRupesh Kumar MishraK. Yugender GoudMona A. MohamedShekher KummariSwapnil TiwariZhanhong LiRoger NarayanLia A. StanciuJean Louis MartyMDPI AGarticleviral diseaseoptical biosensorsdiagnosticsnanomaterialfluorescenceSARS-CoV-2Medicine (General)R5-920ENDiagnostics, Vol 11, Iss 2083, p 2083 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	viral disease optical biosensors diagnostics nanomaterial fluorescence SARS-CoV-2 Medicine (General) R5-920
spellingShingle	viral disease optical biosensors diagnostics nanomaterial fluorescence SARS-CoV-2 Medicine (General) R5-920 Atul Sharma Rupesh Kumar Mishra K. Yugender Goud Mona A. Mohamed Shekher Kummari Swapnil Tiwari Zhanhong Li Roger Narayan Lia A. Stanciu Jean Louis Marty Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update
description	The design and development of biosensors, analytical devices used to detect various analytes in different matrices, has emerged. Biosensors indicate a biorecognition element with a physicochemical analyzer or detector, i.e., a transducer. In the present scenario, various types of biosensors have been deployed in healthcare and clinical research, for instance, biosensors for blood glucose monitoring. Pathogenic microbes are contributing mediators of numerous infectious diseases that are becoming extremely serious worldwide. The recent outbreak of COVID-19 is one of the most recent examples of such communal and deadly diseases. In efforts to work towards the efficacious treatment of pathogenic viral contagions, a fast and precise detection method is of the utmost importance in biomedical and healthcare sectors for early diagnostics and timely countermeasures. Among various available sensor systems, optical biosensors offer easy-to-use, fast, portable, handy, multiplexed, direct, real-time, and inexpensive diagnosis with the added advantages of specificity and sensitivity. Many progressive concepts and extremely multidisciplinary approaches, including microelectronics, microelectromechanical systems (MEMSs), nanotechnologies, molecular biology, and biotechnology with chemistry, are used to operate optical biosensors. A portable and handheld optical biosensing device would provide fast and reliable results for the identification and quantitation of pathogenic virus particles in each sample. In the modern day, the integration of intelligent nanomaterials in the developed devices provides much more sensitive and highly advanced sensors that may produce the results in no time and eventually help clinicians and doctors enormously. This review accentuates the existing challenges engaged in converting laboratory research to real-world device applications and optical diagnostics methods for virus infections. The review’s background and progress are expected to be insightful to the researchers in the sensor field and facilitate the design and fabrication of optical sensors for life-threatening viruses with broader applicability to any desired pathogens.
format	article
author	Atul Sharma Rupesh Kumar Mishra K. Yugender Goud Mona A. Mohamed Shekher Kummari Swapnil Tiwari Zhanhong Li Roger Narayan Lia A. Stanciu Jean Louis Marty
author_facet	Atul Sharma Rupesh Kumar Mishra K. Yugender Goud Mona A. Mohamed Shekher Kummari Swapnil Tiwari Zhanhong Li Roger Narayan Lia A. Stanciu Jean Louis Marty
author_sort	Atul Sharma
title	Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update
title_short	Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update
title_full	Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update
title_fullStr	Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update
title_full_unstemmed	Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update
title_sort	optical biosensors for diagnostics of infectious viral disease: a recent update
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a79d1e12682d48cfb98d3e99903e8887
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Optical Biosensors for Diagnostics of Infectious Viral Disease: A Recent Update

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