TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.

<h4>Background</h4>The -308 G/A polymorphism in the tumor necrosis factor (TNF) gene has been implicated in the risk of acne vulgaris, but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -308 G/A polymorphism and acne vulga...

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Autores principales:	Jian-Kang Yang, Wen-Juan Wu, Jue Qi, Li He, Ya-Ping Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a79ef079a3a74ac4a2338341b58d7ff3
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spelling	oai:doaj.org-article:a79ef079a3a74ac4a2338341b58d7ff32021-11-18T08:34:11ZTNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.1932-620310.1371/journal.pone.0087806https://doaj.org/article/a79ef079a3a74ac4a2338341b58d7ff32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498378/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The -308 G/A polymorphism in the tumor necrosis factor (TNF) gene has been implicated in the risk of acne vulgaris, but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -308 G/A polymorphism and acne vulgaris risk.<h4>Methods</h4>We searched in Pubmed, Embase, Web of Science and CNKI for studies evaluating the association between the -308 G/A gene polymorphism and acne vulgaris risk. Data were extracted and statistical analysis was performed using STATA 12.0 software.<h4>Results</h4>A total of five publications involving 1553 subjects (728 acne vulgaris cases and 825 controls) were included in this meta-analysis. Combined analysis revealed a significant association between this polymorphism and acne vulgaris risk under recessive model (OR = 2.73, 95% CI: 1.37-5.44, p = 0.004 for AA vs. AG + GG). Subgroup analysis by ethnicity showed that the acne vulgaris risk associated with the -308 G/A gene polymorphism was significantly elevated among Caucasians under recessive model (OR = 2.34, 95% CI: 1.13-4.86, p = 0.023).<h4>Conclusion</h4>This meta-analysis suggests that the -308 G/A polymorphism in the TNF gene contributes to acne vulgaris risk, especially in Caucasian populations. Further studies among different ethnicity populations are needed to validate these findings.Jian-Kang YangWen-Juan WuJue QiLi HeYa-Ping ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e87806 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Kang Yang Wen-Juan Wu Jue Qi Li He Ya-Ping Zhang TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.
description	<h4>Background</h4>The -308 G/A polymorphism in the tumor necrosis factor (TNF) gene has been implicated in the risk of acne vulgaris, but the results are inconclusive. The present meta-analysis aimed to investigate the overall association between the -308 G/A polymorphism and acne vulgaris risk.<h4>Methods</h4>We searched in Pubmed, Embase, Web of Science and CNKI for studies evaluating the association between the -308 G/A gene polymorphism and acne vulgaris risk. Data were extracted and statistical analysis was performed using STATA 12.0 software.<h4>Results</h4>A total of five publications involving 1553 subjects (728 acne vulgaris cases and 825 controls) were included in this meta-analysis. Combined analysis revealed a significant association between this polymorphism and acne vulgaris risk under recessive model (OR = 2.73, 95% CI: 1.37-5.44, p = 0.004 for AA vs. AG + GG). Subgroup analysis by ethnicity showed that the acne vulgaris risk associated with the -308 G/A gene polymorphism was significantly elevated among Caucasians under recessive model (OR = 2.34, 95% CI: 1.13-4.86, p = 0.023).<h4>Conclusion</h4>This meta-analysis suggests that the -308 G/A polymorphism in the TNF gene contributes to acne vulgaris risk, especially in Caucasian populations. Further studies among different ethnicity populations are needed to validate these findings.
format	article
author	Jian-Kang Yang Wen-Juan Wu Jue Qi Li He Ya-Ping Zhang
author_facet	Jian-Kang Yang Wen-Juan Wu Jue Qi Li He Ya-Ping Zhang
author_sort	Jian-Kang Yang
title	TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.
title_short	TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.
title_full	TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.
title_fullStr	TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.
title_full_unstemmed	TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.
title_sort	tnf-308 g/a polymorphism and risk of acne vulgaris: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a79ef079a3a74ac4a2338341b58d7ff3
work_keys_str_mv	AT jiankangyang tnf308gapolymorphismandriskofacnevulgarisametaanalysis AT wenjuanwu tnf308gapolymorphismandriskofacnevulgarisametaanalysis AT jueqi tnf308gapolymorphismandriskofacnevulgarisametaanalysis AT lihe tnf308gapolymorphismandriskofacnevulgarisametaanalysis AT yapingzhang tnf308gapolymorphismandriskofacnevulgarisametaanalysis
_version_	1718421639988772864

TNF-308 G/A polymorphism and risk of acne vulgaris: a meta-analysis.

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