The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.
The tumor necrosis factor-receptor-associated factor 2 (TRAF2)- and Nck-interacting kinase (TNIK) is a ubiquitously expressed member of the germinal center kinase family. The TNIK functions in hematopoietic cells and the role of TNIK-TRAF interaction remain largely unknown. By functional proteomics...
Enregistré dans:
Auteurs principaux: | Anna Shkoda, Jennifer A Town, Janine Griese, Michael Romio, Hakan Sarioglu, Thomas Knöfel, Fabian Giehler, Arnd Kieser |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2012
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/a79f619f7332437aa3a8c9f9ef747b27 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation
par: Stefanie Voigt, et autres
Publié: (2020) -
New Look of EBV LMP1 Signaling Landscape
par: Ling Wang, et autres
Publié: (2021) -
Epstein - Barr virus transforming protein LMP-1 alters B cells gene expression by promoting accumulation of the oncoprotein ΔNp73α.
par: Rosita Accardi, et autres
Publié: (2013) -
Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
par: J Luis Espinoza, et autres
Publié: (2012) -
Methodological bases of differential detection of the EBV1/EBV2 and HHV6A/HHV6B
par: M. Popkova, et autres
Publié: (2019)